采用确定性横向位移的微流控循环肿瘤细胞分选器

2021 IEEE International Conference on Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER) Pub Date : 2021-11-19 DOI:10.1109/DISCOVER52564.2021.9663577

S. Ramya, D. Lingaraja, G. Ram, S. Kumar, T. Aravind

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引用次数: 3

摘要

本文通过设计一种新型的微流控通道来预测肿瘤水平，从而分离出$15-30\mu \text{m}$范围内的罕见循环肿瘤细胞(ctc)。预测患者血液样本中ctc的水平将大大降低死亡率。所开发的微通道结构利用了确定性横向位移的概念。临界直径为$42\mu \text{m}$的三角形桩阵列提高了分离效率。通过验证临界直径，分析了乐观微通道的效率。进一步采用粒子跟踪，提高了器件的吞吐率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microfluidic Circulating Tumour Cell Sorter Using Deterministic Lateral Displacement

This paper presents the separation of rare circulating tumour cells (CTCs) in the range of $15-30\mu \text{m}$ by designing the novel microfluidic channel to prognose the level of cancer. Prognosing the level of CTCs in a patient's blood sample will greatly reduce the mortality rate. The developed microchannel structure utilizes the concept of deterministic lateral lateral displacement. Inclusion of arrays of triangular posts with critical diameter of $42\mu \text{m}$ improves the separation efficiency. The optimistic microchannel’s efficiency is analyzed by validating critical diameter. Further particle tracing is employed and improved the device throughput.

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2021 IEEE International Conference on Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER)

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