降低甘油三酯,延长生存期

M. Helvaci, O. Ayyıldız, Orhan Ekrem Muftuoglu
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引用次数: 1

摘要

背景:我们试图确定血浆中最安全的甘油三酯值。方法:将甘油三酯值低于60 mg/dL的病例分为第一组,低于100 mg/dL的病例分为第二组,低于150 mg/dL的病例分为第三组,低于200 mg/dL的病例分为第四组,等于或大于200 mg/dL的病例分为第五组。结果:共纳入478例,其中女性288例,男性190例。年龄、体重、体重指数、甘油三酯和低密度脂蛋白胆固醇的平均值以及吸烟、白毛高血压(WCH)、高血压、2型糖尿病(DM)和冠状动脉疾病(CAD)的患病率几乎在从第一组到第五组的所有步骤中都增加,逐渐且显著(p<0.05)。结论:代谢综合征可能是一种主要影响全身血管内皮的慢性炎症过程,最终以早衰、早死而告终。该综合征具有可逆参数,包括久坐不动的生活方式、富含动物的饮食、超重、吸烟、饮酒、高甘油三酯血症、高脂蛋白血症、血脂异常、空腹血糖受损、糖耐量受损、WCH、慢性炎症和感染,以及不可逆终点,包括肥胖、高血压、糖尿病、肝硬化、外周动脉疾病、慢性阻塞性肺病、慢性肾病、CAD、肠系膜缺血、骨质疏松症和中风。高甘油三酯血症可能是该综合征最重要的可逆参数之一,血浆甘油三酯值越低越好,寿命越长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lower the Triglyceride, Longer the Survival
Background: We tried to determine the safest triglyceride value in the plasma. Methods: Check up cases with a triglyceride value lower than 60 mg/dL were collected into the first, lower than 100 mg/dL into the second, lower than 150 mg/dL into the third, lower than 200 mg/dL into the fourth, and equal to or greater than 200 mg/dL into the fifth groups, respectively. Results: Study included 478 cases (288 females and 190 males), totally. Mean values of age, body weight, body mass index, triglyceride, and low density lipoprotein cholesterol and prevalences of smoking, white coat hypertension (WCH), hypertension, type 2 diabetes mellitus (DM), and coronary artery disease (CAD) increased nearly in all steps from the first towards the fifth groups, gradually and significantly (p<0.05). Conclusions: Probably metabolic syndrome is a chronic inflammatory process mainly affecting the vascular endothelium all over the body and terminating with early aging and premature death. The syndrome has reversible parameters including sedentary life style, animal-rich diet, overweight, smoking, alcohol, hypertriglyceridemia, hyperbetalipoproteinemia, dyslipidemia, impaired fasting glucose, impaired glucose tolerance, WCH, chronic inflammations and infections and irreversible end points including obesity, hypertension, DM, cirrhosis, peripheric artery disease, chronic obstructive pulmonary disease, chronic renal disease, CAD, mesenteric ischemia, osteoporosis, and stroke. Hypertriglyceridemia may be one of the most significant reversible parameters of the syndrome, and it is better to have the lowest plasma triglyceride value as much as possible to live longer.
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