管理生物数据的有效系统

Qian Li, Zhenglu Yang, W. Cao, K. Shimizu
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引用次数: 1

摘要

目前,如何从公共数据库中存储的大量生物数据中快速、方便地获取高质量的数据,特别是某一特定研究领域的数据,是生命科学家们面临的一个难题。在这项工作中,我们开发了一个有效的系统来管理生物数据,这是一类功能重要的膜蛋白;由于蛋白质注释进展缓慢、传递性注释问题以及序列相似度较低,难以从现有数据库中收集到它们。初步系统设计了一个用户友好的web界面,提供:1)针对蛋白质序列标注信息的关键词检索;2)相关文献的推荐,方便研究者对实验结果进行有效比较;3)序列比对服务(NCBI blast+基于blast, HMMER3.0基于隐马尔可夫模型)。我们进行了统计分析,并以可视化的方式展示给研究人员。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An effective system for managing biological data
Nowadays, life scientists grapple with a problem how to fast and easily access/obtain high quality data, especially for a specific research area, from a large amount of biological data deposited in public databases. In this work, we developed an effective system for managing biological data which are a class of functionally important membrane protein; they are hard to collected from the existing databases for slow progress of protein annotations, transitive annotation problem as well as low sequence similarity among them. Our preliminary system was designed with a user-friendly web interface and provides: 1) keywords retrieval against the annotation information of protein sequences, 2) recommendation of the related publications to help researchers conduct effective comparisons of experimental results with convenience, and 3) sequence alignment service (BLAST-based by NCBI blast+ and Hidden Markov Model-based by HMMER3.0). We had conducted a statistical analysis and showed it to the researchers in a visual way.
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