COVID-19患者心血管并发症的发生率

Muhammad R Raza, Irfan Younus Bhatti Rajput, Kashif Zafar, Faiza Altaf, Sobia Aziz
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摘要

背景:由冠状病毒感染引起的大流行已经破坏了整个宇宙的人口。全球新冠肺炎病例迅速增加。COVID-19与许多心血管合并症有关,包括高血压、缺血性心脏病、糖尿病、血脂异常、心房颤动和心力衰竭。目的和目的:了解COVID-19患者心血管并发症的发生率。材料和方法:本观察性队列研究于2021年1月1日至6月31日在古吉拉特邦DHQ医院的冠状病房进行。共216例年龄在18-70岁之间的住院患者,经知情同意后经PCR确诊为COVID-19;已经患有心血管、呼吸系统或其他威胁生命的疾病的患者被排除在外,而高血压、糖尿病和吸烟者被纳入研究。住院时间根据病情的严重程度而定。收集所有患者的详细病史并进行相关检查。通过心电图、超声心动图、肌钙蛋白等检查诊断心血管并发症。所有患者均采用保守治疗。注意心血管并发症的发生频率。临床症状缓解、无发热、胸部x线检查正常且连续两次以上PCR阴性的患者出院。P值<0.05为差异有统计学意义。结果:在216例患者中,30例(14%)为糖尿病患者,21例(10%)为高血压患者。心肌损伤12%(心肌炎4%,心肌梗死1%,肌钙蛋白升高无心肌炎和心电图改变7%血栓栓塞1%,右心室功能障碍5%,心律失常9%)。多数患者症状轻,经保守治疗后恢复。约4-5%的患者需要有创通气支持。年龄、性别、糖尿病、高血压和既往心血管合并症会增加心血管并发症的发生频率。总体死亡率约为2%。P值计算为显著< 0.05。结论:新型冠状病毒肺炎以心血管并发症为主,常见急性心肌损伤、心肌炎、心律失常、血栓栓塞、右心室功能障碍等。这些并发症在患有心血管疾病(CVD)或其他合并症的患者中更为常见
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The frequency of cardiovascular complications in patients suffering from COVID-19
Background: Pandemic caused by Corona virus infection has damaged the population throughout the universe. Cases of COVID-19 increased rapidly in whole world. COVID-19 has been associated with a number of cardiovascular co-morbidities including hypertension, ischemic heart disease, diabetes mellitus, dyslipidemia, atrial fibrillation and cardiac failure. Aims and objective: To determine the frequency of cardiovascular complications in patients with COVID-19. Material and methods: This observational cohort study was conducted in corona ward of DHQ Hospital, Gujrat from 1st January to 31st June 2021. Total 216 patients between 18-70 years of age, admitted who had COVID-19 confirmed by PCR after taking informed consent; patients already suffering from any cardiovascular, respiratory or other life threatening illness were excluded while hypertensive, diabetics and smoker were included in the study. Duration of admission was according to the severity of illness. Detailed history was taken from all patients followed by relevant examination. Investigations like ECG, echocardiographically and troponins were done to diagnose cardiovascular complications. All the patients were treated conservatively. Frequency of cardiovascular complications was noted. The patients who had clinical relief of symptoms, fever free, normal X-Ray chest and at least two consecutive negative PCR results for covid-19 were discharged. p value <0.05 was considered as significant. Results:� Out of two hundred sixteen patients, 30(14%) patients were diabetics and 21(10%) were hypertensive. Myocardial injury in 12% (myocarditis 4%, myocardial infarction 1%, raised troponins without myocarditis and ECG changes in 7% thromboembolism 1%, right ventricle dysfunction 5%, arrhythmias in 9%. Most of the patients had mild symptoms and recovered by conservative management. About 4-5% patients required invasive ventilatory support. Age, gender, diabetes, hypertension and previous cardiovascular co-morbidities increase the frequency of cardiovascular complications. Overall mortality was around 2%. p value was calculated as significant < 0.05. Conclusion: COVID-19 is known for cardiovascular complications in which acute myocardial injury, myocarditis, arrhythmias, thromboembolism, right ventricle dysfunction are common. These complications are more common in those having cardiovascular disease (CVD) or other co-morbidities
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