亲水涂层中钴铁氧体磁性纳米颗粒对双层脂膜电导率的影响

E. Borisova, B. Kozhemova, O. Konstantinov, E. Korepanova, V. Mikheev, A. Mikhnich, V. Sukhova, P. Astanina, O. Koplak, A. Anosov
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引用次数: 0

摘要

磁性纳米颗粒广泛用于医疗应用,例如,作为磁共振成像的造影剂,增强热疗,靶向药物输送,治疗(治疗+诊断)。在体内使用时,磁性纳米颗粒需要一层特殊的涂层来促进生物相容性,并在生理条件下将潜在的毒性降到最低。人血清白蛋白或聚乙二醇可用作涂层。在这项工作中,磁性钴铁氧体纳米颗粒(12和27纳米尺寸)与二苯乙烯酰磷脂酰胆碱双层脂质膜的相互作用进行了研究。膜的电导率变化范围很广——可以区分出两组膜:一组膜的电导率(加入纳米粒子后)与对照组相比几乎没有变化;另一组膜的电导率在加入纳米粒子后突然变化,并在宽范围内增加了0.5-2个数量级。同样体积的12 nm和27 nm纳米颗粒被人血清白蛋白包裹时,电导率没有显著差异。以聚乙二醇包被纳米粒子时,电导率的增加明显弱于以人血清白蛋白包被纳米粒子时。结果表明,亲水性涂覆的磁性纳米颗粒与膜相互作用,导致亚稳导电孔的出现,从而增加膜的整体导电性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EFFECT OF COBALT FERRITE MAGNETIC NANOPARTICLES IN HYDROPHILIC COATING ON THE CONDUCTIVITY OF BILAYER LIPID MEMBRANES
Magnetic nanoparticles are widely used in medical applications, for example, as contrast agents for magnetic resonance imaging, to enhance hyperthermia, for targeted drug delivery, theranostics (therapy + diagnostics). When used in vivo, magnetic nanoparticles require a special coating that promotes biocompatibility and minimizes potential toxicity under physiological conditions. Human serum albumin or polyethylene glycol can be used as a coating. In this work, the interactions of magnetic cobalt ferrite nanoparticles (12 and 27 nm size) with diphitanoylphosphatidylcholine bilayer lipid membranes were investigated. The conductivity of membranes varied over a wide range – two groups of membranes can be distinguished – membranes, the conductivity of which (after the addition of nanoparticles) remained practically unchanged compared to the control, and membranes, the conductivity of which, upon the addition of nanoparticles, changed abruptly and increased in a wide range by 0.5–2 orders of magnitude. Significant differences between the conductivities upon the addition of the same volume of 12 and 27 nm nanoparticles surrounded by human serum albumin were not found. When adding nanoparticles with a coating of polyethylene glycol, the conductivity increased much weaker than when adding nanoparticles with a coating of human serum albumin. The results suggest that hydrophilic coated magnetic nanoparticles interact with the membranes, which can lead to the appearance of metastable conducting pores, which, in turn, increase the integral conductivity of the membranes.
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