成人非酒精性脂肪性肝病的代谢综合征

Zhahid Hassan, M. Latief, Mahroosa Ramzan, F. Abbas, Summyia Farooq
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引用次数: 1

摘要

非酒精性脂肪性肝病(NAFLD)与胰岛素抵抗、肥胖和代谢综合征的其他特征相关。它被认为是肝酶紊乱的最常见原因。最近,NAFLD引起了人们对探索治疗方案的兴趣,包括减肥和饮食干预。NAFLD与代谢综合征的关联已在当代文献中提出。在这项研究中,我们试图探讨NAFLD与代谢综合征的关系。在这项研究中,80名成年NAFLD患者从三级护理医院招募。其中男性42例,女性38例,平均年龄44.46±13.146岁(18 ~ 82岁)。在该患者群体中研究了脂肪肝分级和有无代谢综合征。不符合代谢综合征标准的患者被分为第一组,符合上述标准的患者被分为第二组。1组29例(36.25%),2组51例(63.75%)。1组患者均为I级脂肪肝,2组患者有不同程度的脂肪肝,其中6例为III级脂肪肝。我们发现组1和组2在各种研究参数(肝酶、高密度脂蛋白(HDL)、甘油三酯和血压)上有统计学差异。脂肪肝的超声证据应被视为代谢综合征的预测因素,必须对这些患者进行调查,了解代谢综合征的不同组成部分,以便早期诊断和干预,以改变长期代谢紊乱及其固有并发症的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic Syndrome in Adults with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance, obesity, and other features of metabolic syndrome. It is identified as the most common cause of liver enzyme derangement. Lately, NAFLD has generated interest in exploring treatment options, including weight loss and dietary interventions. An association of NAFLD with metabolic syndrome has been suggested in contemporary literature. In this study, we attempted to look into the association of NAFLD with metabolic syndrome. In this study, 80 adult NAFLD patients were recruited from a tertiary care hospital. Among these, 42 were males and 38 females with a mean age of 44.46±13.146 years (range 18–82 years). Grades of fatty liver and presence or absence of metabolic syndrome were studied in this patient population. Patients who did not qualify for the criteria of met-abolic syndrome were placed in Group 1 and those who fulfilled the stated criteria were considered in Group 2. There were 29 (36.25%) patients in Group 1 and 51 (63.75%) in Group 2. All the patients in Group 1 were having Grade I fatty liver whereas patients in Group 2 were found to having varying grades of fatty liver, with six patients having Grade III fatty liver. We found statistically significant difference in various parameters of study (liver enzymes, high-density lipoprotein (HDL), triglycerides, and blood pressure) between Group 1 and Group 2. Ultrasound evidence of a fatty liver should be considered as a predictor of metabolic syndrome, and these patients must be investigated for the different components of metabolic syndrome so as to have early diagnosis and intervention to alter development of long-term metabolic disorders and their inherent complications.
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