牛奶中的黄曲霉毒素M1:发生及其风险关联:综述

Suliman Mohamed Yousof Sadam, R. Malaka, S. Baco, J. Mustabi
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摘要

黄曲霉毒素M1 (AFM1)是黄曲霉毒素B1 (AFB1)的主要次级代谢物,存在于肝脏中,并在人和动物食用受AFB1污染的食物时排入牛奶中。奶牛从饲料到牛奶的持续时间受不同的饮食和生理因素的影响,包括护理方案、摄食速度、吸收率、动物健康、肝脏生物转化极限和动物的实际产奶量。AFM1暴露可能引起强烈和持续的毒性。在人类中,AFM1暴露与致癌性、遗传毒性、诱变性和致畸性有关。在奶牛中,持续暴露于AFs会降低执行力,削弱肝脏功能,损害抗损伤能力,增加疾病易感性。AFM1的开放性代表了全世界民众的担忧,特别是对于大量饮用牛奶的婴儿和青少年来说,他们对不利的影响更无能为力。AF的鉴定和定量是食品处理确认中的一项关键测试,因为即使是低AF浓度也对人和家畜有害。考虑到这是一种溢价过高的产品,特别是对婴儿和青少年来说,人类在饮食过程中一贯的开放性,促使牛奶和乳制品中AFM1的最极端切断点的负担。同样,根据不同的研究,我们还非常清楚地看到,年轻的动物比成年动物更容易受到黄曲霉毒素的侵害。因此;对年轻的人类和动物来说,AFM1污染牛奶和奶制品应该被认为是不幸的。因此,本文的重点是回顾黄曲霉毒素的发生及其对动物和人类健康的不良影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aflatoxin M1 in Milk: Occurrence and Its Risk Association: A Review
Aflatoxin M1 (AFM1) is the main secondary metabolites of aflatoxin B1 (AFB1) framed in the liver and discharged into milk when people and animals polish off AFB1-polluted food. The persist from feed to milk in dairy cows is affected by different dietary and physiological elements, including taking care of regimens, rate of ingestion, rate of absorption, animal health, hepatic biotransformation limit, and real milk production of the animals. AFM1 exposure might cause both intense and constant toxicity. In humans, AFM1 exposure is related with cancer-causing nature, genotoxicity, mutagenicity, and teratogenicity. In dairy animals, persistent openness to AFs can decrease execution, debilitate liver capability, compromise invulnerable capability, and increment sickness susceptibility. AFM1 openness represents a worry for the worldwide populace, especially for babies and youngsters who drink milk in bounteous amounts and thus, are more powerless to unfavorable impacts. The identification and quantification of AFs represents a critical test in food handling confirmation, since even a low AF concentration is hazardous for people and domesticated animals. Consistent human openness through dietary courses has prompted the burden of most extreme cut off points for AFM1 in milk and dairy products, taking into account that this is a gathering of products with exorbitant premium, particularly for babies and youngsters. Likewise, as per different examinations it is additionally very much felt that youthful animals are additionally observed to be more vulnerable to aflatoxin than grown-ups. Consequently; the defilement of cow milk and milk products by AFM1 ought to be perceived as unfortunate for youthful human and animals. Thus, the point of this paper is to review the occurrence of aflatoxin and its adverse results on animals and human health over the time.
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