用于主动脉和其他心脏结构的纤维增强聚氨酯复合材料的设计

Charmaine Nieves, Sandra Edward, Mayura Kulkarni, Holly M. Golecki
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引用次数: 0

摘要

当患者出现心力衰竭时,医疗设备可以支持失去的心脏功能。然而,生物组织和设备之间的顺应性不匹配为长期整合带来了挑战。例如,硅胶,一种用于软机器人医疗设备的常见聚合物,在体内植入时会产生负面的副作用。本文通过测试聚氨酯复合材料的力学性能,探讨替代材料的仿生性能。测试表明我们的复合材料与心脏和主动脉的天然组织有相似之处。当植入织物增强弹性体外壳(fabREEs)时,我们的复合致动器的行为与天然主动脉组织相似。通过分析执行器中的环向和纵向应力,我们提出了用于构建用于移植或台式测试的主动脉模型的候选材料。我们表明,这些材料可以用来模拟一系列心脏组织,未来的医疗设备设计将受益于在新设备中考虑这些软材料复合材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
DESIGN OF FABRIC-REINFORCED POLYURETHANE COMPOSITES FOR AORTIC AND OTHER CARDIAC CONSTRUCTS
When patients experience heart failure, medical devices can support lost cardiac function. However, compliance mismatch between biological tissues and devices present challenges for long term integration. For example, silicone, a common polymer used in soft robotic medical devices, has negative side effects when implanted in vivo. This paper explores biomimetic properties of alternative materials by testing mechanical properties of polyurethane composites. Testing reveals similarities between our composites and native tissues in the heart and aorta. When built into fabric reinforced elastomeric enclosures (fabREEs), our composite actuators behave similar to native aortic tissue. By analyzing hoop and longitudinal stresses in actuators, we present candidate materials for building aortic models for use in transplantations or benchtop testing. We show that these materials can serve to mimic a range of cardiac tissues and that future of medical device design will benefit from considering these soft material composites in new devices.
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