具有高序列复杂性的糖尿病相关蛋白的数学分析

A. A. Rao, Bhremeramba, G. Sridhar
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引用次数: 1

摘要

我们已经寻找了影响糖尿病的蛋白质,我们也发现了这些蛋白质在哪些常见物种中更普遍,并对那些具有高序列复杂性的蛋白质进行了蛋白质组成分析。大约90%的大鼠基因在小鼠和人类基因组中有对应的基因,这就是在三种不同物种中发现共同蛋白质的原因(大鼠基因组测序协会2004年,www.ratbehaviour.org/Ratsmice.htm)。检查了蛋白质变量的分布模式,并进一步绘制了双变量图。双变量图显示褐家鼠和小家鼠的聚类相似,但在智人中显示出一些差异,这表明该图是正确的,因为褐家鼠和小家鼠在系统发育树上相对接近(Sridhar, GR. et al),因此具有相似的聚类。远离簇的蛋白质是异常值,因为它们具有不同的组成特征
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mathematical Analysis of Diabetes Related Proteins Having High Sequence Complexity
We have searched for proteins affecting diabetes and we also found in which common species these proteins were more prevalent and have performed protein composition analysis of those having high sequence complexity. About 90% of rat genes have counterparts in the mouse and human genomes and this is the reason to find proteins common among the three different species (Rat Genome Sequencing Consortium 2004, www.ratbehaviour.org/Ratsmice.htm). The distribution pattern of the protein variates was examined and bivariate plots were further drawn. The bivariate plots show a similar clustering for Rattus norvegicus and Mus musculus but show some variation in Homo sapiens indicating that the plots are correct as Rattus norvegicus and Mus musculus are relatively close in the phylogenetic tree (Sridhar, GR. et al) hence having a similar clustering. The proteins which are away from the cluster are outliers due to the reason that they are having different compositional characteristics
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