{"title":"吗啡耐受猴脑内蛋白质合成。","authors":"M A Hollinger, K F Killam, G A Deneau","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Most investigations dealing with brain protein synthesis in opiate tolerant animals have been restricted to rodent species (rat, mouse and rabbit). We now report data obtained from the monkey (Macaca mulatta). In vivo incorporation of [U-14C]lysine into acid-precipitable protein of various areas of normal and opiate tolerant primate brain was studied. Exposure of the animals to a 1 hour pulse of the radioactive amino acid resulted in no significant difference in the incorporation rate into protein of 16 discrete brain areas.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 3","pages":"319-25"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vivo protein synthesis in morphine tolerant monkey brain.\",\"authors\":\"M A Hollinger, K F Killam, G A Deneau\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Most investigations dealing with brain protein synthesis in opiate tolerant animals have been restricted to rodent species (rat, mouse and rabbit). We now report data obtained from the monkey (Macaca mulatta). In vivo incorporation of [U-14C]lysine into acid-precipitable protein of various areas of normal and opiate tolerant primate brain was studied. Exposure of the animals to a 1 hour pulse of the radioactive amino acid resulted in no significant difference in the incorporation rate into protein of 16 discrete brain areas.</p>\",\"PeriodicalId\":76387,\"journal\":{\"name\":\"Psychopharmacology communications\",\"volume\":\"1 3\",\"pages\":\"319-25\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology communications","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vivo protein synthesis in morphine tolerant monkey brain.
Most investigations dealing with brain protein synthesis in opiate tolerant animals have been restricted to rodent species (rat, mouse and rabbit). We now report data obtained from the monkey (Macaca mulatta). In vivo incorporation of [U-14C]lysine into acid-precipitable protein of various areas of normal and opiate tolerant primate brain was studied. Exposure of the animals to a 1 hour pulse of the radioactive amino acid resulted in no significant difference in the incorporation rate into protein of 16 discrete brain areas.
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