实验性冠状动脉血栓形成对区域和全身血浆色谱模式的影响。

P Chowdhury, C B Moschos
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引用次数: 0

摘要

对实验性冠状动脉血栓形成犬的血浆色谱图变化进行了评价。在2小时、4小时和24小时的时间内,同时从主动脉和冠状动脉窦连续取样。除凝胶层析法外,免疫扩散法和电泳法也用于鉴定洗脱组分的蛋白质成分。结果表明,在冠状动脉血栓闭塞后2小时内,正常的色谱模式从对照组向左移动,并维持了24小时。左移可能是由于由于血栓形成过程而形成的重分子量组分的较早洗脱。早期出现的改变的色谱模式构成了一个重要的优势,值得进一步探索可能的诊断应用在人类受试者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of experimental coronary thrombosis upon regional and systemic plasma chromatographic patterns.

An evaluation of changes in the plasma chromatographic pattern was carried out in dogs with experimental coronary thrombosis. Sequential samples were taken simultaneously from the aorta and coronary sinus over a two, four and twenty-four hour period. In addition to gel-chromatography, immunodiffusion and electrophoresis were also employed to identify the protein components of the elution fractions. The results showed that there was a shift of the normal chromatographic pattern to the left from the control within two hours following thrombotic occlusion of the coronary artery and it was maintained over a twenty-four hour period. The shift to the left was presumably due to the earlier elution of the heavy molecular weight components forming as a result of the thrombotic process. The early appearance of the altered chromatographic pattern constitutes an important advantage worthy of further exploration for possible diagnostic application in the human subject.

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