J R Hobbs, P M Carter, K B Cooke, M Foster, C J Oon
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Our current methods for establishing the presence of an IgM paraprotein will be outlined, after which the clinical presentation of patients bearing such proteins will be considered under three main headings: (1) with symptoms due to the protein; (2) with symptoms due to the tumour; (3) with paraproteinaemia as a chance finding. IgM paraproteins usually show narrow electrophoretic bands, having a single type of gt chain combined with a single class of light chain (,u-chain disease is discussed separately elsewhere in the Symposium). Some are cryoglobulins or act as cold
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