胆囊收缩素注射后或饱腹后的十二指肠运动

J.A. Deutsch, T.R. Thiel, L.H. Greenberg
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引用次数: 26

摘要

在大鼠十二指肠一侧植入光电池,另一侧植入发光二极管。这允许记录自由运动动物的上十二指肠活动。当大鼠进食到饱时,给它们注射胆囊收缩素的末端八肽或生理盐水,就会产生这样的记录。虽然胆囊收缩素减少了50%以上的摄入量,但注射胆囊收缩素后十二指肠活动的幅度与正常饱足后的活动相比明显减弱。因此,胆囊收缩素注射后食物摄入量的减少可能是由于这种异常而不是正常的饱腹感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Duodenal motility after cholecystokinin injection or satiety

Rats were implanted with a photocell on one side of the duodenum and a light emitting diode on the other. This permitted recordings of upper duodenal activity in the freely moving animal. Such recordings were made when rats were injected with the terminal octapeptide of cholecystokinin or saline as they fed to satiety. While cholecystokinin reduced intake by over 50%, the amplitude of duodenal activity after cholecystokinin injection was grossly attenuated as compared with activity after normal satiation. Food intake reduction after cholecystokinin injection may therefore be due to this abnormality rather than normal satiety.

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