合成muramyl-二肽(MDP) n -乙酰muramyl- l- alanyl- d -异谷氨酰胺的免疫佐剂作用。

Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-10-01

B Heymer, H Finger, C H Wirsing

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摘要

研究了合成的muramyl-dipeptide (MDP) n -acetyl-muramyl- alanyl- d -异谷氨酰胺对BSA和SRBC小鼠免疫的佐剂活性。发现MDP显著增加BSA抗体的形成，有利于诱导对BSA的过敏反应。相比之下，在上述条件下，MDP对SRBC的免疫反应只有微弱的刺激。

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Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.

The adjuvant activity of the synthetic muramyl-dipeptide (MDP) N-acetyl-muramyl-L-alanyl-D-isoglutamine upon immunization of mice with BSA or SRBC was studied. MDP was found to significantly increase BSA-antibody formation and to favour the induction of anaphylactic reactions to BSA. In contrast, under the conditions employed, MDP only weakly stimulated the immune response to SRBC.

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Zeitschrift fur Immunitatsforschung. Immunobiology

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