Sidekick动态地重新平衡收缩和突出的力量来控制组织形态发生

The Journal of Cell Biology Pub Date : 2022-03-08 DOI:10.1083/jcb.202107035

Jacob Malin, Christian Rosa Birriel, Sergio Astigarraga, J. Treisman, V. Hatini

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引用次数: 6

摘要

Malin等人的研究表明，亲同质粘附分子Sidekick与WAVE调节复合体和三细胞粘附连接处的Polychaetoid/Zonula occludence-1交替相互作用，动态地重新平衡对立的伸缩力，这些伸缩力反复扩大和收缩细胞接触，以维持细胞间接触并确保适当的上皮重塑。

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Sidekick dynamically rebalances contractile and protrusive forces to control tissue morphogenesis

Malin et al. show that the homophilic adhesion molecule Sidekick interacts alternately with the WAVE regulatory complex and with Polychaetoid/Zonula occludence-1 at tricellular adherens junctions to dynamically rebalance opposing protrusive and contractile forces that repeatedly expand and contract cell contacts to maintain cell–cell contacts and ensure proper epithelial remodeling.

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来源期刊

The Journal of Cell Biology

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