喀拉拉邦中部三级保健中心严重钩端螺旋体病行为和社会预测因素的病例对照研究

Anjely Sukumaran, A. Biju
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引用次数: 0

摘要

钩端螺旋体病是一种重要的全球性人畜共患疾病。该病是由致病性钩端螺旋体引起的。感染源于直接或间接接触受感染的宿主动物,这些宿主动物在其肾小管中携带病原体,并通过尿液排出致病性钩端螺旋体病。本研究旨在评估严重钩端螺旋体病的社会和行为预测因素,并研究严重钩端螺旋体病患者的临床特征和转归。148例钩端螺旋体病患者被分为严重组和非严重组。我们的大多数研究人群都有风险因素,如通过赤脚、耕作、游泳、养牛、接触污水和停滞的雨水接触土壤或水。诸如无法充分获得安全饮用水和环境卫生服务、个人卫生习惯不良、识字率低以及无法获得保健服务等条件,都加剧了感染的脆弱性,并阻碍了预防工作。严重程度的预测因素是在出现症状之前割伤或损伤、因发热和周围肌痛而服用非甾体抗炎药、转诊晚和开始使用抗生素、急性肾损伤、胰腺炎、心肌炎、血小板减少症、急性肝损伤、血小板少于50,000和INR延长。了解严重钩端螺旋体病的危险因素可以改善预防和控制措施,以减轻严重病例的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case-Control Study of Behavioural and Social Predictors of Severe Leptospirosis in a Tertiary Care Centre, Central Kerala
Leptospirosis is a globally important zoonotic disease. The disease is caused by pathogenic Leptospira species. Infections result from direct or indirect exposure to infected reservoir animals that carry the pathogen in their renal tubules and shed pathogenic leptospirosis in the urine. This study was conducted to assess the social and behavioural predictors of severe Leptospirosis and to study the clinical profile and outcome of patients with severe leptospirosis .148 patients with leptospirosis were divided into severe and non-severe groups. The majority of our study population had risk factors like contact with soil or water through barefoot, farming, swimming, cattle rearing, contact with sewage and stagnant rainwater. Conditions such as inadequate access to safe drinking water and sanitation services, poor personal hygiene practices, low levels of literacy, and lack of access to health services, contribute to increased vulnerability to infection and work against prevention efforts. Severity predictor factors are Cut or injury prior to symptoms, NSAID intake for fever and Myalgia from the periphery, late referral and late initiation of antibiotics, acute kidney injury, pancreatitis, myocarditis, thrombocytopenia, ARDS, acute liver injury, platelet less than 50,000 and prolonged INR. Knowledge about risk factors for severe leptospirosis can improve prevention and control measures to mitigate the incidence of severe cases.
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