下颌追踪技术在体积调制弧线治疗中的剂量学影响

B. Park, B. Cho, Jong Hoon Kim, Sang‐wook Lee, S. Ahn, J. Kwak
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引用次数: 3

摘要

目的:为了减少辐射光束在多叶准直器(MLC)阻挡区域的传输,研究了下颌跟踪技术。本研究的目的是对体积调制弧线治疗(VMAT)中下颌跟踪技术的剂量学评价。材料与方法:采用下颌追踪技术治疗的VMAT患者31例,采用固定下颌重新规划,分析规划靶体积(PTV)和危险器官体积(OARs)对剂量学的影响。治疗部位为肝、肺、胰腺。在下颌跟踪和固定下颌条件下,使用治疗计划系统对所有计划进行优化和计算,使处方剂量覆盖到95%的PTV (D95%)。评估了治疗方案的剂量学验证、靶剂量分布的均匀性、桨叶中的部分体积剂量和低剂量体积,以验证下颌跟踪的剂量学影响。结果:与固定下颌技术相比,下颌追踪技术似乎能够提供一些临床优势。下颌跟踪法和固定颌法的靶区剂量均匀性相似。下颌追踪技术对肝癌患者的肾脏(p=0.008)和十二指肠(p=0.028)、肺癌患者的食道(p=0.015)、胰腺癌患者的正常肝脏(p=0.005)和肾脏(p=0.005)的部分体积剂量均有显著降低。当有效最大场尺寸比pvs等效球直径大1.5 cm时,计算出下颌跟踪技术的低剂量体积小于固定下颌设置的低剂量体积。结论:应用下颌追踪技术可显著降低OARs的部分体积剂量和低剂量体积,且对VMAT靶点的剂量学参数无不良影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dosimetric Impact of the Jaw-Tracking Technique in Volumetric Modulated ArcTherapy
Objective: The jaw-tracking technique has been developed to reduce the radiation beam transmission in the regions blocked by multileaf collimator (MLC). The aim of this study is the dosimetric evaluation of the jaw-tracking technique in Volumetric Modulated Arc Therapy (VMAT). Material and Methods: 31 VMAT cases treated with the jaw-tracking technique were employed and re-planned with fixed jaw to analyze the dosimetric influences of the planning target volume (PTV) and organs at risk (OARs) volume. The treatment sites were liver, lung, and pancreas. All plans were optimized and calculated under jawtracking and fixed jaw conditions to cover the prescription dose to 95% of PTV (D95%) using the treatment planning system. The dosimetric verification of the treatment plans, the uniformity of the target dose distributions, the partial volume doses in OARs, and the low-dose volume were evaluated to verify the dosimetric impact of the jaw-tracking. Results: The jaw-tracking technique appeared to be able to provide some clinical advantages compared to the fixed-jaw technique. The dose uniformities in targets were similar between in jaw-tracking technique and in fixed jaw. It appeared that the jaw-tracking technique could significantly reduce the partial volume dose of OARs, for the kidney (p=0.008) and duodenum (p=0.028) in liver cancer cases, for the esophagus (p=0.015) in the lung cancer cases, and for the normal liver (p=0.005) and kidney (p=0.005) in the pancreatic cancer cases. The low-dose volumes with the jaw tracking technique were calculated to be smaller than those with fixed jaw setup when the effective maximum field dimension were 1.5 cm larger than the equivalent spherical diameter of the PTVs. Conclusions: The partial volume dose of OARs and the low-dose volume could be significantly reduced by application of the jaw-tracking technique without any adverse effect of the dosimetric parameter for targets in VMAT.
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