将一万亿点数据转化为治疗、诊断和对疾病的新见解

A. Butte
{"title":"将一万亿点数据转化为治疗、诊断和对疾病的新见解","authors":"A. Butte","doi":"10.1145/2512089.2512102","DOIUrl":null,"url":null,"abstract":"There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte's lab at Stanford builds and applies tools that convert more than a trillion points of molecular, clinical, and epidemiological data - measured by researchers and clinicians over the past decade - into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight his lab's work on using publicly-available molecular measurements to find new uses for drugs including drug repositioning for inflammatory bowel disease, discovering new treatable inflammatory mechanisms of disease in type 2 diabetes, and the evaluation of patients presenting with whole genomes sequenced.","PeriodicalId":143937,"journal":{"name":"Data and Text Mining in Bioinformatics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Translating a trillion points of data into therapies, diagnostics, and new insights into disease\",\"authors\":\"A. Butte\",\"doi\":\"10.1145/2512089.2512102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte's lab at Stanford builds and applies tools that convert more than a trillion points of molecular, clinical, and epidemiological data - measured by researchers and clinicians over the past decade - into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight his lab's work on using publicly-available molecular measurements to find new uses for drugs including drug repositioning for inflammatory bowel disease, discovering new treatable inflammatory mechanisms of disease in type 2 diabetes, and the evaluation of patients presenting with whole genomes sequenced.\",\"PeriodicalId\":143937,\"journal\":{\"name\":\"Data and Text Mining in Bioinformatics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Data and Text Mining in Bioinformatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1145/2512089.2512102\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Data and Text Mining in Bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1145/2512089.2512102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

迫切需要将基因组时代的发现转化为临床应用,但是从实验室到床边的转化的困难已经很好地描述了。新兴的转化生物信息学领域可能会有所帮助。Butte博士在斯坦福大学的实验室建立并应用工具,将研究人员和临床医生在过去十年中测量的超过一万亿点的分子、临床和流行病学数据转化为诊断、治疗和对疾病的新见解。Butte博士是一名生物信息学家和儿科内分泌学家,他将重点介绍他的实验室在利用公开可用的分子测量方法寻找药物新用途方面的工作,包括针对炎症性肠病的药物重新定位,发现2型糖尿病疾病的新的可治疗炎症机制,以及对全基因组测序患者的评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Translating a trillion points of data into therapies, diagnostics, and new insights into disease
There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte's lab at Stanford builds and applies tools that convert more than a trillion points of molecular, clinical, and epidemiological data - measured by researchers and clinicians over the past decade - into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight his lab's work on using publicly-available molecular measurements to find new uses for drugs including drug repositioning for inflammatory bowel disease, discovering new treatable inflammatory mechanisms of disease in type 2 diabetes, and the evaluation of patients presenting with whole genomes sequenced.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信