翼状胬肉切除自体结膜移植术后类固醇性高眼压的发生率及危险因素

Raymond DK Toseafa, I. Braimah, N. N. Tagoe, B. Abaidoo, Y. Adam, Edith M Dogbe, V. Essuman
{"title":"翼状胬肉切除自体结膜移植术后类固醇性高眼压的发生率及危险因素","authors":"Raymond DK Toseafa, I. Braimah, N. N. Tagoe, B. Abaidoo, Y. Adam, Edith M Dogbe, V. Essuman","doi":"10.46829/hsijournal.2023.6.4.1.448-456","DOIUrl":null,"url":null,"abstract":"Background: Topical steroids are used to reduce post-operative inflammation after ocular surgery with the potential risk of ocular hypertension, glaucoma and blindness. There is a paucity of published data globally and locally on steroid-induced ocular hypertension (SiOH) post pterygium excision(PE) with conjunctival autograft (CAG). \nObjective: We aimed to determine the incidence and risk factors of SiOH post-PE with CAG in Korle-Bu Teaching Hospital, Accra, Ghana.\nMethods: In this prospective observational study, the demographic and clinical data of patients undergoing PE with CAG were collected and analyzed. Post-operative intraocular pressures (IOP) were measured on days 1, 7, 14, 28, and 42. The cumulative incidence of SiOH (proportion of the increase in IOP ≥10mmHg at six weeks compared to baseline) and mean change in IOP from baseline were computed. Risk factors of SiOH were determined using a multiple logistic regression model. The Kaplan-Meier survival curve was used in estimating the median time to develop SiOH.\nResults: Overall, 101 patients participated in this study with a mean age of 46.8±11.9 years. The majority (65.3%, n= 66/101) of participants were females. The mean pre-operative IOP in the study eyes was 15.3±3.0 mmHg. The overall mean post-operative IOP was 18.6±2.8 mmHg (p= 0.001). The overall incidence of SiOH six weeks post-PE with CAG was 32.7% (95% confidence interval (CI)= 23.7-42.7%). Male sex was the only independent factor associated with the development of SiOH [odds ratio (OR) = 3.3; 95% CI = 1.1-9.7; p= 0.032]. The median time to develop SiOH was 42 days (95% CI= 37.1-46.9 days, p= 0.022).\nConclusion: The study showed that SiOH post-PE is a common complication with an overall six-weeks post-excision incidence of 32.7%. Males are more likely to develop SiOH after PE with CAG. Patients undergoing PE with CAG should be closely monitored postoperatively to prevent complications associated with prolonged raised IOP.","PeriodicalId":285465,"journal":{"name":"Health Sciences Investigations Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Incidence and risk factors of steroid-induced ocular hypertension following pterygium excision with conjunctival autograft\",\"authors\":\"Raymond DK Toseafa, I. Braimah, N. N. Tagoe, B. Abaidoo, Y. Adam, Edith M Dogbe, V. Essuman\",\"doi\":\"10.46829/hsijournal.2023.6.4.1.448-456\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Topical steroids are used to reduce post-operative inflammation after ocular surgery with the potential risk of ocular hypertension, glaucoma and blindness. There is a paucity of published data globally and locally on steroid-induced ocular hypertension (SiOH) post pterygium excision(PE) with conjunctival autograft (CAG). \\nObjective: We aimed to determine the incidence and risk factors of SiOH post-PE with CAG in Korle-Bu Teaching Hospital, Accra, Ghana.\\nMethods: In this prospective observational study, the demographic and clinical data of patients undergoing PE with CAG were collected and analyzed. Post-operative intraocular pressures (IOP) were measured on days 1, 7, 14, 28, and 42. The cumulative incidence of SiOH (proportion of the increase in IOP ≥10mmHg at six weeks compared to baseline) and mean change in IOP from baseline were computed. Risk factors of SiOH were determined using a multiple logistic regression model. The Kaplan-Meier survival curve was used in estimating the median time to develop SiOH.\\nResults: Overall, 101 patients participated in this study with a mean age of 46.8±11.9 years. The majority (65.3%, n= 66/101) of participants were females. The mean pre-operative IOP in the study eyes was 15.3±3.0 mmHg. The overall mean post-operative IOP was 18.6±2.8 mmHg (p= 0.001). The overall incidence of SiOH six weeks post-PE with CAG was 32.7% (95% confidence interval (CI)= 23.7-42.7%). Male sex was the only independent factor associated with the development of SiOH [odds ratio (OR) = 3.3; 95% CI = 1.1-9.7; p= 0.032]. The median time to develop SiOH was 42 days (95% CI= 37.1-46.9 days, p= 0.022).\\nConclusion: The study showed that SiOH post-PE is a common complication with an overall six-weeks post-excision incidence of 32.7%. Males are more likely to develop SiOH after PE with CAG. Patients undergoing PE with CAG should be closely monitored postoperatively to prevent complications associated with prolonged raised IOP.\",\"PeriodicalId\":285465,\"journal\":{\"name\":\"Health Sciences Investigations Journal\",\"volume\":\"56 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Sciences Investigations Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46829/hsijournal.2023.6.4.1.448-456\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Sciences Investigations Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46829/hsijournal.2023.6.4.1.448-456","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:外用类固醇用于减少眼部手术后的炎症,有潜在的高眼压、青光眼和失明的风险。全球和本地关于翼状胬肉切除(PE)联合自体结膜移植(CAG)后类固醇性高眼压(SiOH)的发表数据都很缺乏。目的:我们旨在确定加纳阿克拉Korle-Bu教学医院CAG术后SiOH的发生率和危险因素。方法:在这项前瞻性观察研究中,收集并分析CAG合并PE患者的人口学和临床资料。术后第1、7、14、28、42天测量眼内压(IOP)。计算SiOH的累积发病率(与基线相比,6周IOP≥10mmHg增加的比例)和IOP与基线相比的平均变化。采用多元logistic回归模型确定SiOH的危险因素。Kaplan-Meier生存曲线用于估计发生SiOH的中位时间。结果:101例患者参加了本研究,平均年龄46.8±11.9岁。大多数(65.3%,n= 66/101)参与者为女性。研究眼术前平均IOP为15.3±3.0 mmHg。术后总平均IOP为18.6±2.8 mmHg (p= 0.001)。pe合并CAG后6周SiOH的总发生率为32.7%(95%可信区间(CI)= 23.7-42.7%)。男性是与SiOH发生相关的唯一独立因素[优势比(OR) = 3.3;95% ci = 1.1-9.7;p = 0.032)。发生SiOH的中位时间为42天(95% CI= 37.1-46.9天,p= 0.022)。结论:本研究显示pe后SiOH是一种常见的并发症,术后6周总发生率为32.7%。男性在PE合并CAG后更容易发生SiOH。术后应密切监测伴有CAG的PE患者,以防止与IOP延长升高相关的并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence and risk factors of steroid-induced ocular hypertension following pterygium excision with conjunctival autograft
Background: Topical steroids are used to reduce post-operative inflammation after ocular surgery with the potential risk of ocular hypertension, glaucoma and blindness. There is a paucity of published data globally and locally on steroid-induced ocular hypertension (SiOH) post pterygium excision(PE) with conjunctival autograft (CAG). Objective: We aimed to determine the incidence and risk factors of SiOH post-PE with CAG in Korle-Bu Teaching Hospital, Accra, Ghana. Methods: In this prospective observational study, the demographic and clinical data of patients undergoing PE with CAG were collected and analyzed. Post-operative intraocular pressures (IOP) were measured on days 1, 7, 14, 28, and 42. The cumulative incidence of SiOH (proportion of the increase in IOP ≥10mmHg at six weeks compared to baseline) and mean change in IOP from baseline were computed. Risk factors of SiOH were determined using a multiple logistic regression model. The Kaplan-Meier survival curve was used in estimating the median time to develop SiOH. Results: Overall, 101 patients participated in this study with a mean age of 46.8±11.9 years. The majority (65.3%, n= 66/101) of participants were females. The mean pre-operative IOP in the study eyes was 15.3±3.0 mmHg. The overall mean post-operative IOP was 18.6±2.8 mmHg (p= 0.001). The overall incidence of SiOH six weeks post-PE with CAG was 32.7% (95% confidence interval (CI)= 23.7-42.7%). Male sex was the only independent factor associated with the development of SiOH [odds ratio (OR) = 3.3; 95% CI = 1.1-9.7; p= 0.032]. The median time to develop SiOH was 42 days (95% CI= 37.1-46.9 days, p= 0.022). Conclusion: The study showed that SiOH post-PE is a common complication with an overall six-weeks post-excision incidence of 32.7%. Males are more likely to develop SiOH after PE with CAG. Patients undergoing PE with CAG should be closely monitored postoperatively to prevent complications associated with prolonged raised IOP.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信