抑制β淀粉样蛋白聚集的潜在治疗肽和载体的设计

2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG) Pub Date : 2012-10-18 DOI:10.1109/ENBENG.2012.6331364

J. Loureiro, M. Coelho, S. Rocha, Maria do Carmo Pereira

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引用次数: 3

摘要

淀粉样蛋白β肽(Aβ)的构象改变和聚集与阿尔茨海默病(AD)有关。这项工作的目的是研究在带电和非离子型两亲体存在下Aβ的结构和纤维组装，以及β-破片肽/偶联物。预计这些分子将抑制Aβ聚集。脂质体系统将被开发为这些肽缀合物的载体，以穿过脑血屏障(BBB)。

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Design of potential therapeutic peptides and carriers to inhibit amyloid β peptide aggregation

The conformational changes and aggregation of amyloid β peptide (Aβ) are associated to Alzheimer's disease (AD). The aim of this work is to study the structure and fibril assembly of Aβ in the presence of charged and nonionic amphiphiles, and β-sheet breaker peptides/conjugates. It is expected that these molecules will inhibit Aβ aggregation. Liposome systems will be developed as carriers for these peptide conjugates to cross the brain blood barrier (BBB).

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2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG)

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