Bikona Ghosh, D. Sánchez-Velazco, Parvati Prem, Anam S Ali, Olivia Dominique, Shahtaj A Shah, Luis Morales Ojeda, Dinali Obeysekera
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Data extraction utilized a template based on the Cochrane Consumers and Communication Review group’s extraction guidelines. Out of 166 studies identified, 12 relevant studies were extensively analyzed. The trials consistently demonstrated accelerated reepithelialization, improved patient compliance in managing burn-related pain, no immunologic or allergic reactions, reduced infection rates, shorter hospital stays, and decreased treatment costs when using fish skin. These findings suggest that fish skin is comparable to traditional treatments in terms of effectiveness and safety. Considering the discussed advantages, Nile tilapia fish skin emerges as a promising xenograft option for burn victims. However, further large-scale trials and studies are needed before its widespread and official implementation in burn centers. 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The trials consistently demonstrated accelerated reepithelialization, improved patient compliance in managing burn-related pain, no immunologic or allergic reactions, reduced infection rates, shorter hospital stays, and decreased treatment costs when using fish skin. These findings suggest that fish skin is comparable to traditional treatments in terms of effectiveness and safety. Considering the discussed advantages, Nile tilapia fish skin emerges as a promising xenograft option for burn victims. However, further large-scale trials and studies are needed before its widespread and official implementation in burn centers. 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引用次数: 0
摘要
根据美国疾病控制与预防中心的数据,美国每年有110万人因烧伤入院,约4500人死亡。尽管自1869年以来,皮肤移植一直是标准的治疗方法,但最近的研究表明,罗非鱼皮肤可以提供一种更安全、更有效的替代方法。本综述旨在评估与烧伤患者使用鱼皮相关的优势和知识差距。系统检索PubMed、Scopus、Web of Science、Clinicaltrials.gov、Google Scholar等电子数据库,使用2018 - 2022年相关MESH关键词进行检索。搜索和分析遵循“系统评价和荟萃分析的首选报告项目”方法。数据提取使用了基于Cochrane消费者与沟通评估小组提取指南的模板。在确定的166项研究中,对12项相关研究进行了广泛分析。试验一致表明,使用鱼皮可加速表皮再生,提高患者对烧伤相关疼痛的依从性,无免疫或过敏反应,降低感染率,缩短住院时间,降低治疗费用。这些发现表明,鱼皮在有效性和安全性方面与传统疗法相当。考虑到所讨论的优点,尼罗罗非鱼鱼皮成为烧伤患者有前途的异种移植选择。然而,在烧伤中心广泛和正式实施之前,还需要进一步的大规模试验和研究。需要更多的研究来确定鱼皮作为一种可行的治疗方式的有效性和安全性。
Use of Nile tilapia fish skin in treatment for burn victims
Burn injuries in the United States result in 1.1 million hospital admissions, with around 4500 deaths annually, according to the CDC. Although skin grafts have been the standard treatment since 1869, recent research suggests that tilapia skin could offer a safer and more effective alternative. This review aims to assess the strengths and knowledge gaps related to the usage of fish skin in burn patients. A systematic search was conducted on electronic databases, such as PubMed, Scopus, Web of Science, Clinicaltrials.gov, and Google Scholar, using relevant MESH keywords from 2018 to 2022. The search and analysis followed the “Preferred Reporting Items for Systematic Reviews and Meta-analysis” methodology. Data extraction utilized a template based on the Cochrane Consumers and Communication Review group’s extraction guidelines. Out of 166 studies identified, 12 relevant studies were extensively analyzed. The trials consistently demonstrated accelerated reepithelialization, improved patient compliance in managing burn-related pain, no immunologic or allergic reactions, reduced infection rates, shorter hospital stays, and decreased treatment costs when using fish skin. These findings suggest that fish skin is comparable to traditional treatments in terms of effectiveness and safety. Considering the discussed advantages, Nile tilapia fish skin emerges as a promising xenograft option for burn victims. However, further large-scale trials and studies are needed before its widespread and official implementation in burn centers. More research is required to establish the efficacy and safety of fish skin as a viable treatment modality.