SIRT1基因rs12778366多态性与年龄相关性黄斑变性风险的关联

Journal of Ophthalmology & Clinical Research Pub Date : 2022-10-14 DOI:10.24966/ocr-8887/100097

Dmitrenko Op, Karpova Ns, Abramova Oi, Nurbekov Mk, Arshinova Es

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摘要

加性遗传模型中的C等位基因和共显性和隐性模型中的TC杂合基因型是易患此病的遗传因素(p< 0.001, OR: 2,121, 95% CI: 1.435 ~ 3.133;p<0.001, OR: 2.499, 95% CI: 1.595-3.915;p<0.001, OR: 2.507, 95% CI: 1.612-3.900)。此外，C等位基因在女性AMD患者和65岁以上的AMD患者中更为常见，这可能与AMD的高风险有关

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Association of Polymorphism rs12778366 of the SIRT1 Gene with the Risk of Age-Related Macular Degeneration

The C allele in the additive inheritance model and the TC heterozygous genotype in the codominant and recessive models serve as the genetic factor predisposing to this disease (p<0,001, OR: 2,121, 95% of CI: 1.435-3.133; p<0.001, OR: 2.499, 95% of CI: 1.595-3.915; p<0.001, OR: 2.507, 95% of CI: 1.612-3.900). In addition, the C allele was more common in women with AMD and in AMD patients over 65 years of age, which may be associated with a higher risk of AMD

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Journal of Ophthalmology & Clinical Research

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