Acute and chronic effect of aspirin on selected endurance variables

The purpose of the study was to determine the influence of acute and chronic ingestion of aspirin on selected endurance variables during maximal exercise. Eleven moderately trained men (19 to 30 years old) participated in three blind graded maximal treadmill tests for each of two different aspirin doses and a placebo condition. The treatments consisted of the following: an acute dose of 975 mg of aspirin 1 hour prior to exercise; a chronic dose of 975 mg of aspirin 3 times a day for 4 consecutive days; and a placebo of three comstarch‐filled capsules, 3 times a day for 4 consecutive days. Maximal performance was not significantly different among the treatments. However, chronic treatment resulted in significantly higher 5‐minute postexercise lactate levels (p < 0.001), a decrease in time to reach ventilatory threshold (Tvent), and a shorter time to exhaustion (p < 0.01) compared with the acute and placebo treatment Acute treatment also resulted in significantly higher 5‐minute postexercise lactate concent...