硝呋替莫对克氏锥虫以外的其他锥虫科实验感染的影响。

Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie Pub Date : 1979-07-01

A Haberkorn

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引用次数: 0

摘要

研究了硝呋替莫对布氏锥虫、刚果锥虫、马属锥虫、装备锥虫、伊瓦西锥虫、冈比亚锥虫、路易氏锥虫、罗得西亚锥虫、间日锥虫、多诺瓦利什曼原虫和热带锥虫的影响。该药物对所有这些细菌都有活性，但对不同种类和不同菌株的罗得西亚锥虫的敏感性存在较大差异。对于罗得西亚锥虫的治疗，单一的高剂量比相同剂量分多次小剂量施用更有效。后一种剂量方案更适合克氏体和路易斯体的治疗。多诺瓦氏乳杆菌和热带乳杆菌对硝呋替莫有反应，但仅在体外有反应。

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The effect of nifurtimox on experimental infections with trypanosomatidae other than Trypanosoma cruzi.

The influence of Nifurtimox on Trypanosoma brucei, T. congolense, T. equinum, T. equiperdum, T. evansi, T. gambiense, T. lewisi, T. rhodesiense, T. vivax, Leishmania donovani and L. tropica has been studied in animals and in vitro. The drug was active against all of them but there are considerable differences in sensitivity of the various species as well as of different strains of T. rhodesiense. For the treatment of T. rhodesiense a single high dosage was more efficient than the same dose divided into many smaller applications. The latter dose schedule is more suitable for the treatment of T. cruzi and T. lewisi. L. donovani and L. tropica responded to Nifurtimox but only in vitro.

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Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie

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