pH值及其他变量对胶原纳米纤维物理性能的影响

2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME) Pub Date : 2018-11-01 DOI:10.1109/ICBME.2018.8703549

S. Mahdavi, M. Abdekhodaie, S. Mashayekhan

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引用次数: 0

摘要

本研究考察了温度和聚合物浓度对中性和酸性胶原纳米纤维形成的影响。中性和酸性电纺丝胶原纳米纤维的直径分别为90 ~ 220 nm和160 ~ 310 nm。此外，酸性胶原溶液具有更稳定的射流和较少的珠状形成。傅里叶变换红外光谱显示，只有中性样品在低于25°C的温度下，胶原蛋白三螺旋结构得以维持，而酸性胶原蛋白则向随机螺旋结构过渡。因此，对于支架的应用，如pH，聚合物的浓度和温度等因素可以改变。

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Effect of pH along with other variables on physical properties of collagen nanofibers

In this study the effects of temperature and polymer concentration were examined on the formation of neutral and acidic collagen nanofibers using benign solution. Neutral and acidic electrospun collagen nanofibers diameter were in the range of 90 to 220 nm and 160 to 310 nm respectively. Moreover, the acidic collagen solution had more stable jets and less bead formation was observed.` Fourier transform infrared spectroscopy showed the maintenance of the collagen triple helix at the temperature lower than 25°C for only neutral samples and the transition to the random coil in acidic collagen. In consequence, regarding the application of the scaffold factors such as pH, concentration of the polymer and temperature can be altered.

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2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)

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