职业性慢性阻塞性肺病——最被忽视的职业性肺病?

N. Murgia, A. Gambelunghe
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引用次数: 27

摘要

慢性阻塞性肺疾病(COPD)是由接触有毒颗粒和气体引起的。吸烟是主要的危险因素,但其他因素也与慢性阻塞性肺病有关。职业暴露于蒸汽、气体、粉尘和烟雾有助于COPD的发生和进展,占人口归因比例的14%。工作场所污染物,特别是无机粉尘,可引发气道损伤和炎症,这是COPD发病机制的标志。职业性慢性阻塞性肺病仍未得到充分诊断,主要是由于在临床环境中评估该疾病的职业成分存在挑战,特别是在存在其他风险因素的情况下。有必要对临床医生进行专门的教育和培训,并开展研究,重点评估职业暴露在导致慢性阻塞性肺病中的作用。早期诊断和确定职业性病因对于防止肺功能进一步下降和减轻慢性阻塞性肺病的健康和社会经济负担非常重要。由全科医生或呼吸内科医生建立详细的职业史可以帮助确定个体COPD患者的职业负担,提供第一个有用的干预措施(戒烟,最佳治疗管理等)。一旦患者被诊断为职业性慢性阻塞性肺病,在获得专业职业医学和公共卫生服务方面存在广泛的国际差异,同时在工作场所和收入支持方面也存在限制。因此,需要初级保健医生、呼吸内科医生和职业医学专家之间的紧密合作,以帮助管理COPD患者的健康和社会问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Occupational COPD—The most under‐recognized occupational lung disease?
Chronic obstructive pulmonary disease (COPD) is caused by exposure to noxious particles and gases. Smoking is the main risk factor, but other factors are also associated with COPD. Occupational exposure to vapours, gases, dusts and fumes contributes to the development and progression of COPD, accounting for a population attributable fraction of 14%. Workplace pollutants, in particular inorganic dust, can initiate airway damage and inflammation, which are the hallmarks of COPD pathogenesis. Occupational COPD is still underdiagnosed, mainly due to the challenges of assessing the occupational component of the disease in clinical settings, especially if other risk factors are present. There is a need for specific education and training for clinicians, and research with a focus on evaluating the role of occupational exposure in causing COPD. Early diagnosis and identification of occupational causes is very important to prevent further decline in lung function and to reduce the health and socio‐economic burden of COPD. Establishing details of the occupational history by general practitioners or respiratory physicians could help to define the occupational burden of COPD for individual patients, providing the first useful interventions (smoking cessation, best therapeutic management, etc.). Once patients are diagnosed with occupational COPD, there is a wide international variation in access to specialist occupational medicine and public health services, along with limitations in workplace and income support. Therefore, a strong collaboration between primary care physicians, respiratory physicians and occupational medicine specialists is desirable to help manage COPD patients' health and social issues.
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