白藜芦醇在心血管疾病预防中的应用综述

Gabriela Marujo Góes, Amanda Silva Fraga, A. Ladeia
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引用次数: 0

摘要

白藜芦醇是一种在黑莓和红酒中发现的多酚化合物,具有预防动脉粥样硬化的特性,因此可以预防心血管疾病。本研究的目的是通过一项系统综述,评估白藜芦醇是否能降低高危人群心血管事件的发生率,改善炎症和内皮功能障碍。在LILACS、PubMed、SCIELO等数据库和选定的人类随机对照试验中进行了搜索,包括使用白藜芦醇预防心血管事件或改善炎症和内皮功能。最终的样本包含10个项目。在分析肱动脉血流介导扩张的四项研究中,与安慰剂相比,所有研究都显示使用白藜芦醇后内皮功能有显著改善。在7项评估亚临床炎症的研究中,有差异,3项研究显示TNF-α值明显降低,2项研究显示血浆c反应蛋白和白细胞介素6 (IL-6)水平有显著变化,1项研究未显示TNF-α和IL-6的变化。总之,与安慰剂相比,白藜芦醇能够改善内皮功能。然而,由于从研究中提取的数据不足,因此无法推断内皮炎症相关参数的改善与否。此外,由于文献中没有随机对照试验记录分析白藜芦醇使用对人类临床结果的影响,因此不可能评估白藜芦醇在改善生存、梗死或降低死亡率方面的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
USE OF RESVERATROL IN CARDIOVASCULAR DISEASES PREVENTION: A SYSTEMATIC REVIEW
Resveratrol, a polyphenolic compound found in blackberry and red wine, has properties that prevent the development of atherosclerosis, and therefore, cardiovascular disease. The aim of this study was, through a systematic review, to assess whether resveratrol reduces the incidence of cardiovascular events and improves inflammation and endothelial dysfunction in individuals at risk. Searches were conducted in databases such as LILACS, PubMed,SCIELO and selected randomized controlled trials in humans, including the use of resveratrol in the prevention of cardiovascular events or in the improvement of inflammation and endothelial function. The final sample consisted of 10 items. Of the four studies that analyzed the flow-mediated dilatation of the brachial artery, all showed significant improvement in endothelial function after the use of resveratrol, compared with placebo.In the 7 studies that evaluated subclinical inflammation, there were differences, 3 studies showed significant decreases in the values of TNF-α, 2 showed significant changes in plasma levels of C-reactive protein and interleukin 6 (IL-6), while 1 didn't showed changes in TNF-α and IL-6. In conclusion, resveratrol is capable of improving endothelial function when compared with placebo. However, it was not possible to infer an improvement or not in the parameters concerning endothelial inflammation, since the data extracted from the studies were insufficient. Moreover, it was not possible to evaluate the use of resveratrol in the improvement of survival, infarction or reduction in mortality, since there were no records in the literature of randomized controlled trials that analyzed the effect of resveratrol use on clinical outcomes in humans.
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