R. Hussain, N. Krumpa, J. Strachan, D. Clarke, U. Wagner, B. Macdonald, D. Reading, T. Cobb, I. Gillingham, A. Price, M. Smith, G. Siligardi
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引用次数: 7
摘要
同步加速器圆二色性(CD)已经成为研究蛋白质折叠、构象变化和酶机制以及二级结构测定的一种有价值的技术。令人兴奋的新的潜在应用存在于蛋白质折叠，蛋白质组学的蛋白质复合物形成和功能基因组学的配体/药物筛选。利用金刚石光源的3 GeV同步加速器，我们可以准直一个非常小的光束(约2 mm (H) × 1 mm (V))，具有高光子通量(估计为8 × 1013 (ph/s/0.1%bw)，在6 eV和300 mA)。小光束尺寸将使以前不可能测量的更小的样本量成为可能。
DESIGN OF B23 CIRCULAR DICHROISM BEAMLINE AT DIAMOND LIGHT SOURCE
Synchrotron circular dichroism (CD) is already a valuable technique for studies of protein folding, conformational changes and enzyme mechanisms, as well as secondary structure determination. Exciting new potential applications exist in protein folding, protein complex formation for Proteomics, and ligand/drug screening for Functional Genomics. With the 3 GeV synchrotron of Diamond Light Source we can collimate a very small size light beam (about 2 mm (H) × 1 mm (V)) with high photon flux (estimated 8 × 1013 (ph/s/0.1%bw) at 6 eV and 300 mA). The small beam size will enable the measurement of smaller sample volumes that previously has not been possible.
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