微流控信号发生器对加利福尼亚海杉神经节的化学刺激

2008 IEEE Biomedical Circuits and Systems Conference Pub Date : 2008-11-01 DOI:10.1109/BIOCAS.2008.4696935

F. Azizi, C. Mastrangelo, Hui Lu, H. Chiel

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引用次数: 1

摘要

我们实现了一种微流控信号发生器芯片，用于局部化学刺激下加利福尼亚海百合神经系统的体外研究。PDMS芯片实现了一个位脉冲编码调制器，该调制器以数字方式控制直接注射在神经节上方的非水解胆碱能激动剂碳醇的浓度。芯片成功地诱导了一种摄食模式的爆发。

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Chemical stimulation of Aplysia californica ganglion with microfluidic signal generators

We implemented a microfluidic signal generator chip for the in-vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The PDMS chip implements a one-bit pulse-code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in inducing a burst of ingestive patterns.

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2008 IEEE Biomedical Circuits and Systems Conference

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