Study of Optimal Administration Method of Tazobactam / Piperacillin Using Monte Carllo Simulation

Monte Carlo simulation method was used to examine optimal administration method of Tazobactam / Piperacillin （ TAZ/PIPC ） against Pseudomonas aeruginosa （ P. aeruginosa ）． The dose to obtain≥50% Time above MIC （ %T>MIC ） by renal functions and target attainment rates （ TA% ） ≥80% ware calculated for 12 administration methods. Pharmacokinetic parameters were established according to population pharmacokinetic analyses in Japanese patients with pneumonia, whereas MIC was determined using the MIC 90 from the antibiogram of P. aeruginosa isolated at the Yamaguchi Hospital in a 5‑year period starting in 2011. Our recommended criteria for optimum administration was TA with 50%T ＞ MIC, and prioritizing facility for the patient （ low‑dose, lower frequencies and shorter infusion time ）． The suggest a recommendation of for patients with creatinine CLcr for patients with CLcr mL/min, CLcr infusion in CLcr≥80mL/min there was variation in MIC 90 levels between periods ： some cases have much higher MIC 90 value, in which case the optimal dosage could not be recommended within the indicated