G. Furtmüller, Madeline L. Fryer, S. Ganguly, J. Budihardjo, B. Oh, D. Cooney, G. Raimondi, W. Lee, L. Luznik, G. Brandacher
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Post Transplantation High-dose Cyclophosphamide (PTCy) to Promote Immune Tolerance After Reconstructive Transplantation
The life-long use of immunosuppressants and their associated toxicities remains one of the primary obstacles that curtail the wider use of VCAs for reconstruction. In this study we therefore investigated if the combination of bone marrow transplantation and high dose cyclophosphamide induces a state of long term allograft acceptance in the setting of full thickness skin transplantation and orthotopic hind limb transplantation in a mouse model.
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