A. Kawczyk-Krupka, Marta Kaleta-Richter, A. Międzybrodzka, W. Latos, A. Sieroń, G. Cieślar
{"title":"金丝桃素介导的光动力治疗对体外结肠癌细胞分泌特定白细胞介素的影响","authors":"A. Kawczyk-Krupka, Marta Kaleta-Richter, A. Międzybrodzka, W. Latos, A. Sieroń, G. Cieślar","doi":"10.1117/12.2525516","DOIUrl":null,"url":null,"abstract":"Aim of the study was to determine the immune effect of PDT with hypericin (HY-PDT) used in sublethal doses on the secretion of Interleukin 8 and 10 by experimental models of residual colon cancer cells in vitro. Results HY-PDT amplified the secretion of IL-8 by SW620 cell line, but the decrease of IL-8 secreted by the SW480 cell line. The increase in secretion of IL-10 was noticed in the SW480 cell line, but the changes of secretion IL-10 by SW 620 was not noted. SW480 cell line without PDT secreted higher levels of IL-8 and IL-10 than SW620 cells. Based on these research findings it could be told, that PDT both eliminates and control primary tumors using cytotoxic effect while HY-PDT at lower doses can modulate function of tumor microenvironment by releasing interleukins depended on metastatic activity of tumor cells.","PeriodicalId":267589,"journal":{"name":"World Congress of the International Photodynamic Association","volume":"150 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The influence of hypericin-mediated photodynamic therapy on secretion of selected interleukins by colon cancer cells in vitro\",\"authors\":\"A. Kawczyk-Krupka, Marta Kaleta-Richter, A. Międzybrodzka, W. Latos, A. Sieroń, G. Cieślar\",\"doi\":\"10.1117/12.2525516\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim of the study was to determine the immune effect of PDT with hypericin (HY-PDT) used in sublethal doses on the secretion of Interleukin 8 and 10 by experimental models of residual colon cancer cells in vitro. Results HY-PDT amplified the secretion of IL-8 by SW620 cell line, but the decrease of IL-8 secreted by the SW480 cell line. The increase in secretion of IL-10 was noticed in the SW480 cell line, but the changes of secretion IL-10 by SW 620 was not noted. SW480 cell line without PDT secreted higher levels of IL-8 and IL-10 than SW620 cells. Based on these research findings it could be told, that PDT both eliminates and control primary tumors using cytotoxic effect while HY-PDT at lower doses can modulate function of tumor microenvironment by releasing interleukins depended on metastatic activity of tumor cells.\",\"PeriodicalId\":267589,\"journal\":{\"name\":\"World Congress of the International Photodynamic Association\",\"volume\":\"150 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Congress of the International Photodynamic Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1117/12.2525516\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Congress of the International Photodynamic Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.2525516","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The influence of hypericin-mediated photodynamic therapy on secretion of selected interleukins by colon cancer cells in vitro
Aim of the study was to determine the immune effect of PDT with hypericin (HY-PDT) used in sublethal doses on the secretion of Interleukin 8 and 10 by experimental models of residual colon cancer cells in vitro. Results HY-PDT amplified the secretion of IL-8 by SW620 cell line, but the decrease of IL-8 secreted by the SW480 cell line. The increase in secretion of IL-10 was noticed in the SW480 cell line, but the changes of secretion IL-10 by SW 620 was not noted. SW480 cell line without PDT secreted higher levels of IL-8 and IL-10 than SW620 cells. Based on these research findings it could be told, that PDT both eliminates and control primary tumors using cytotoxic effect while HY-PDT at lower doses can modulate function of tumor microenvironment by releasing interleukins depended on metastatic activity of tumor cells.
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