评价维生素D对ⅰ期和ⅱ期A级牙周炎患者唾液和血清白细胞介素-8水平的影响。

A. Saleh, M. Fekry, mostafa hoseny
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引用次数: 0

摘要

目的:评价维生素D联合1期牙周治疗对牙周炎I期和II期A级患者GCF、唾液和血清IL-8水平的影响。对象和方法:共有40名医学上健康的成人牙周炎I期和II级A级患者,其中20名患者在服用维生素D (1 α - 0.5mcg) 1粒胶囊的基础上,每天进行全口牙龈上和牙龈下的洗牙和牙根规划,持续6个月。对照组:20例患者仅行全口龈上、龈下刮治和牙根刨平。治疗前及治疗后3、6个月龈沟液、血、唾液标本采集:临床评价及血清维生素D水平、血清、唾液及龈沟液中IL-8水平。结果:研究组治疗6个月后较基线平均维生素D %升高(↑117.41±46.82)高于对照组(↑2.77±20.34),且研究组GCF IL-8降低8%,对照组升高,观察3个月和6个月。在3个月时,研究组显示血清il比基线降低8%。6个月时,研究组血清il水平较基线下降8%,而对照组升高。维生素D与IL-8呈负相关。结论:补充维生素D可降低牙周病的严重程度。维生素D可能通过抑制IL-8的表达而起到抑制牙周炎症的作用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the effect of vitamin D on the salivary and serum levels of interleukin-8 in patients with periodontitis stage I and II grade A.
Objectives: Evaluate the effect of vitamin D in conjugation with phase 1 periodontal therapy on the GCF, salivary and serum level of IL-8 in periodontitis stage I and II grade A patients. Subjects and Methods: A total of 40 medically healthy adult subjects with periodontitis stage I and II grade A. Twenty patients received a full mouth supra –and sub-gingival scaling and root planning, in addition to vitamin D (one alpha 0.5mcg) one capsules daily for 6 months. Control group: twenty patients received a full mouth supra – and sub-gingival scaling and root planing only. Samples Collection of Gingival Crevice Fluid, blood samples and saliva before treatment and 3 and 6 months after: Clinical evaluation and Serum level of vitamin D, Serum, salivary and GCF levels of IL-8. Results: Study group after treatment for 6 months showed a higher mean vitamin D % increase ( ↑ 117.41 ± 46.82) from baseline than control group ( ↑ 2.77±20.34) The results showed, also,that study group reported a reduction in GCF IL-8 % while control group increased, at both observation period of 3and 6 month. At 3 months, study group showed a reduction in Serum IL-8% from baseline than control group. At 6 months, Study group showed a reduction in Serum IL-8% from baseline while control group increased. There was a negative correlation between vitamin D and IL-8. Conclusion: Vitamin D supplementation may reduce the severity of periodontal disease. Vitamin D may have a potential role in the inhibition of periodontal inflammation by inhibiting the IL-8 expression
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