{"title":"评价维生素D对ⅰ期和ⅱ期A级牙周炎患者唾液和血清白细胞介素-8水平的影响。","authors":"A. Saleh, M. Fekry, mostafa hoseny","doi":"10.21608/ajdsm.2021.95374.1240","DOIUrl":null,"url":null,"abstract":"Objectives: Evaluate the effect of vitamin D in conjugation with phase 1 periodontal therapy on the GCF, salivary and serum level of IL-8 in periodontitis stage I and II grade A patients. Subjects and Methods: A total of 40 medically healthy adult subjects with periodontitis stage I and II grade A. Twenty patients received a full mouth supra –and sub-gingival scaling and root planning, in addition to vitamin D (one alpha 0.5mcg) one capsules daily for 6 months. Control group: twenty patients received a full mouth supra – and sub-gingival scaling and root planing only. Samples Collection of Gingival Crevice Fluid, blood samples and saliva before treatment and 3 and 6 months after: Clinical evaluation and Serum level of vitamin D, Serum, salivary and GCF levels of IL-8. Results: Study group after treatment for 6 months showed a higher mean vitamin D % increase ( ↑ 117.41 ± 46.82) from baseline than control group ( ↑ 2.77±20.34) The results showed, also,that study group reported a reduction in GCF IL-8 % while control group increased, at both observation period of 3and 6 month. At 3 months, study group showed a reduction in Serum IL-8% from baseline than control group. At 6 months, Study group showed a reduction in Serum IL-8% from baseline while control group increased. There was a negative correlation between vitamin D and IL-8. Conclusion: Vitamin D supplementation may reduce the severity of periodontal disease. Vitamin D may have a potential role in the inhibition of periodontal inflammation by inhibiting the IL-8 expression","PeriodicalId":117944,"journal":{"name":"Al-Azhar Journal of Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the effect of vitamin D on the salivary and serum levels of interleukin-8 in patients with periodontitis stage I and II grade A.\",\"authors\":\"A. Saleh, M. Fekry, mostafa hoseny\",\"doi\":\"10.21608/ajdsm.2021.95374.1240\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: Evaluate the effect of vitamin D in conjugation with phase 1 periodontal therapy on the GCF, salivary and serum level of IL-8 in periodontitis stage I and II grade A patients. Subjects and Methods: A total of 40 medically healthy adult subjects with periodontitis stage I and II grade A. Twenty patients received a full mouth supra –and sub-gingival scaling and root planning, in addition to vitamin D (one alpha 0.5mcg) one capsules daily for 6 months. Control group: twenty patients received a full mouth supra – and sub-gingival scaling and root planing only. Samples Collection of Gingival Crevice Fluid, blood samples and saliva before treatment and 3 and 6 months after: Clinical evaluation and Serum level of vitamin D, Serum, salivary and GCF levels of IL-8. Results: Study group after treatment for 6 months showed a higher mean vitamin D % increase ( ↑ 117.41 ± 46.82) from baseline than control group ( ↑ 2.77±20.34) The results showed, also,that study group reported a reduction in GCF IL-8 % while control group increased, at both observation period of 3and 6 month. At 3 months, study group showed a reduction in Serum IL-8% from baseline than control group. At 6 months, Study group showed a reduction in Serum IL-8% from baseline while control group increased. There was a negative correlation between vitamin D and IL-8. Conclusion: Vitamin D supplementation may reduce the severity of periodontal disease. Vitamin D may have a potential role in the inhibition of periodontal inflammation by inhibiting the IL-8 expression\",\"PeriodicalId\":117944,\"journal\":{\"name\":\"Al-Azhar Journal of Dental Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Al-Azhar Journal of Dental Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ajdsm.2021.95374.1240\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Al-Azhar Journal of Dental Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ajdsm.2021.95374.1240","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of the effect of vitamin D on the salivary and serum levels of interleukin-8 in patients with periodontitis stage I and II grade A.
Objectives: Evaluate the effect of vitamin D in conjugation with phase 1 periodontal therapy on the GCF, salivary and serum level of IL-8 in periodontitis stage I and II grade A patients. Subjects and Methods: A total of 40 medically healthy adult subjects with periodontitis stage I and II grade A. Twenty patients received a full mouth supra –and sub-gingival scaling and root planning, in addition to vitamin D (one alpha 0.5mcg) one capsules daily for 6 months. Control group: twenty patients received a full mouth supra – and sub-gingival scaling and root planing only. Samples Collection of Gingival Crevice Fluid, blood samples and saliva before treatment and 3 and 6 months after: Clinical evaluation and Serum level of vitamin D, Serum, salivary and GCF levels of IL-8. Results: Study group after treatment for 6 months showed a higher mean vitamin D % increase ( ↑ 117.41 ± 46.82) from baseline than control group ( ↑ 2.77±20.34) The results showed, also,that study group reported a reduction in GCF IL-8 % while control group increased, at both observation period of 3and 6 month. At 3 months, study group showed a reduction in Serum IL-8% from baseline than control group. At 6 months, Study group showed a reduction in Serum IL-8% from baseline while control group increased. There was a negative correlation between vitamin D and IL-8. Conclusion: Vitamin D supplementation may reduce the severity of periodontal disease. Vitamin D may have a potential role in the inhibition of periodontal inflammation by inhibiting the IL-8 expression