横轴小管系统在心室肌细胞中的生理作用:模拟研究

Computers in Cardiology, 2005 Pub Date : 1900-01-01 DOI:10.1109/CIC.2005.1588276

M. Pásek, J. Šimurda, C. Orchard, G. Christé

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引用次数: 1

摘要

将豚鼠和大鼠心室肌细胞横轴管系统的实验数据纳入其电活动的定量模型。模拟的结果表明，活动依赖的Ca2+在管腔内消耗减少细胞内Ca2+负荷和细胞内Ca2+瞬态在两个物种。然而，在消耗的幅度、频率依赖性和对细胞活动的影响方面，观察到相当大的物种差异

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Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study

Experimental data related to the transverse-axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion of Ca2+ within the tubular lumen decreases the intracellular Ca2+ load and intracellular Ca2+ transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed

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Computers in Cardiology, 2005

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