{"title":"上转化纳米颗粒嵌入聚酯纳米载体的光学、胶体和生物学特性","authors":"D. Wawrzyńczyk, J. Kulbacka, U. Bazylińska","doi":"10.1117/12.2271694","DOIUrl":null,"url":null,"abstract":"We have investigated the change in optical properties and biocompatibility of up-converting NaYF4 nanoparticles (NPs) upon encapsulation inside the polyester nanocarriers (NCs) stabilized by Crempophor RH40 (CRH40), poly(D,L-lactide) (PLA), Pluronic P123 (P123). NaYF4:Er3+,Yb3+ NPs showed intense green and red emission, and upon encapsulation the increase of red band in respect to green one was observed, with no luminescence lifetime shortening. Obtained NCs showed prolonged colloidal stability and protective effect of the polymer shell simultaneously preserving the high emission efficiency of nanoparticles embedded within the silicon oil (SO) core. Based on emission spectra, kinetic measurements and cytotoxicity studies upon human malignant melanoma Me45 cell line we have shown the advantages of using polyester NCs as containers for the up-converting NPs. Due to the possibility of co-encapsulation of photosensitizers the obtained nanocarriers showed potential for application in theranostics.","PeriodicalId":150522,"journal":{"name":"Applications of Optics and Photonics","volume":"121 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers\",\"authors\":\"D. Wawrzyńczyk, J. Kulbacka, U. Bazylińska\",\"doi\":\"10.1117/12.2271694\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We have investigated the change in optical properties and biocompatibility of up-converting NaYF4 nanoparticles (NPs) upon encapsulation inside the polyester nanocarriers (NCs) stabilized by Crempophor RH40 (CRH40), poly(D,L-lactide) (PLA), Pluronic P123 (P123). NaYF4:Er3+,Yb3+ NPs showed intense green and red emission, and upon encapsulation the increase of red band in respect to green one was observed, with no luminescence lifetime shortening. Obtained NCs showed prolonged colloidal stability and protective effect of the polymer shell simultaneously preserving the high emission efficiency of nanoparticles embedded within the silicon oil (SO) core. Based on emission spectra, kinetic measurements and cytotoxicity studies upon human malignant melanoma Me45 cell line we have shown the advantages of using polyester NCs as containers for the up-converting NPs. Due to the possibility of co-encapsulation of photosensitizers the obtained nanocarriers showed potential for application in theranostics.\",\"PeriodicalId\":150522,\"journal\":{\"name\":\"Applications of Optics and Photonics\",\"volume\":\"121 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applications of Optics and Photonics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1117/12.2271694\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applications of Optics and Photonics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.2271694","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
我们研究了在由Crempophor RH40 (CRH40)、聚(D, l -丙交酯)(PLA)、Pluronic P123 (P123)稳定的聚酯纳米载体(nc)内包封上转化的NaYF4纳米颗粒(NPs)的光学性质和生物相容性的变化。NaYF4:Er3+，Yb3+ NPs表现出强烈的绿色和红色发射，包封后红带相对绿带增加，但发光寿命没有缩短。所制备的纳米颗粒具有较长的胶体稳定性和聚合物外壳的保护作用，同时保持了嵌入硅油(SO)芯内的纳米颗粒的高发射效率。基于对人类恶性黑色素瘤Me45细胞系的发射光谱、动力学测量和细胞毒性研究，我们已经证明了使用聚酯NCs作为上转化NPs容器的优势。由于光敏剂共包封的可能性，所获得的纳米载体在治疗学上具有应用潜力。
Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers
We have investigated the change in optical properties and biocompatibility of up-converting NaYF4 nanoparticles (NPs) upon encapsulation inside the polyester nanocarriers (NCs) stabilized by Crempophor RH40 (CRH40), poly(D,L-lactide) (PLA), Pluronic P123 (P123). NaYF4:Er3+,Yb3+ NPs showed intense green and red emission, and upon encapsulation the increase of red band in respect to green one was observed, with no luminescence lifetime shortening. Obtained NCs showed prolonged colloidal stability and protective effect of the polymer shell simultaneously preserving the high emission efficiency of nanoparticles embedded within the silicon oil (SO) core. Based on emission spectra, kinetic measurements and cytotoxicity studies upon human malignant melanoma Me45 cell line we have shown the advantages of using polyester NCs as containers for the up-converting NPs. Due to the possibility of co-encapsulation of photosensitizers the obtained nanocarriers showed potential for application in theranostics.
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