前列腺癌:罗马尼亚的职业危害?

D. Mates, V. Calotă, M. Oțelea, I. Csiki, Ș. Rașcu, C. Staicu, N. Suciu, A. Voinoiu, P. Iordache, A. Rascu, I. Mateș, A. Manolescu, V. Jinga
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引用次数: 0

摘要

一些职业致癌物(砷、镉)和工业(橡胶生产)与前列腺癌风险有关,但大多数数据来自对筛查人群进行的研究。在这里,我们探讨了罗马尼亚男性的这种关联,这是一个PSA筛查覆盖率低的人群。我们分析了在ROMCAN项目中招募的468例病理确诊的前列腺癌病例和495例非肿瘤医院对照。通过访谈收集个人信息,包括职业活动。两位专家将工作和活动分为15个具有相似暴露模式的经济部门。使用逻辑回归计算比值比(ORs)和95%置信区间(ci),以确定在每个经济部门工作与前列腺癌风险之间的关系。我们观察到,电力、燃气、蒸汽和空调供应活动(OR=3.95, p=0.029)、制造-轻工业(OR=1.88, p=0.039)、金融、保险和赌博(OR=1.44, p=0.046)的就业风险较高,而建筑行业的就业风险较低(OR=0.62, p=0.010)。在调整潜在混杂因素后,只有建筑工人的低风险维持不变(OR=0.55, p=0.004)。我们的研究为职业因素在前列腺癌风险中的作用提供了一些证据,但还需要进一步的评估。应在工作场所加强健康生活方式的宣传和预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prostate cancer: an occupational hazard in Romania?
Abstract Several occupational carcinogens (arsenic, cadmium) and industries (rubber production) have been associated with prostate cancer risk but most of the data are from studies conducted on screened populations. Here we explored this association in Romanian men, a population with low PSA screening test coverage. We have analyzed 468 prostate cancer cases pathologically confirmed and 495 non-cancer hospital controls, recruited in the ROMCAN project. Personal information, including occupational activity, was collected through interview. Two experts classified jobs and activities into 15 economic sectors with similar patterns of exposure. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between ever employed in each economic sector and prostate cancer risk. We observed a higher non adjusted risk for employment in electricity, gas, steam and air conditioning supply activities (OR=3.95, p=0.029), manufacturing–light industry (OR=1.88, p=0.039), financial, insurance and gambling (OR=1.44, p=0.046) and a lower risk for employment in construction industry (OR=0.62, p=0.010). After adjusting for potential confounders, only the low risk in construction workers was maintained (OR=0.55, p=0.004). Our study provides some evidence on the role of occupational factors on the prostate cancer risk but further assessments are needed. Healthy lifestyle promotion and prevention should be reinforced at workplaces.
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