Cervical Cancer in Case with Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI)

: Background: Combined cervical cancer and pelvic organ prolapse (POP) is extremely uncommon and there is no standard treatment guideline for the complex comorbidity. We attempted to provide a treatment strategy and explore possible reasons for the comorbidities. Case presentation: We presented a 62-year-old patient seeking treatment for postmenopausal tissue prolapse and leakage of urine. The gynecologic examination revealed the uterine prolapse with a 2.5 cm papillary and erosive lesion on the cervix that was pathologically confirmed as cervical squamous cell carcinoma in stage Ib1. Clinical diagnosis included cervical squamous cell carcinoma in stage Ib1, prolapse of uterus and vagina, stress urinary incontinence (SUI). Then she was performed radical surgery for cervical cancer and tension-free vaginal tape-obturator (TVT-O). The urine function was good after operation. The surgery solved two diseases, which improved the quality of life (QOL) of patient and radically cured cervical carcinoma at the same time. Follow up for more than two years, HPV was negative, no prolapse symptoms occurred, and the quality of life was good. Conclusions: Surgical-based treatment seems to be more suitable that can cure the two diseases and improve the QOL. We should pay attention to the potential high incidence of HPV infection and HPV-related cervical cancer so that we should not ignore the screening for cervical cancer in the prolapse group and initiate surgery treatment strategies of cervical cancer or pre-cancerous lesions as early as possible to reach an optimal outcome of patient.