I. Gmoshinski, V. Shipelin, N. Riger, A. Balakina, N. V. Trusov, G. Guseva, S. Khotimchenko
{"title":"大鼠亚急性口服镍纳米颗粒的毒性作用","authors":"I. Gmoshinski, V. Shipelin, N. Riger, A. Balakina, N. V. Trusov, G. Guseva, S. Khotimchenko","doi":"10.3390/materproc2022009021","DOIUrl":null,"url":null,"abstract":": The toxic effects have been evaluated of Nickel nanoparticles (NiNPs) at their 92-day oral administration to male Wistar rats at doses of 0.1; 1 and 10 mg/kg body weight. An increase in glycemia, triglyceride, LDL, total protein, and its globulin fraction levels were noticed in NiNPs exposed rats. NiNPs caused a decrease in the reserves of reduced liver glutathione and excretion of selenium in the urine, an increase in serum levels of cytokines IL-1β, IL-2, IL-6, IL-12p70, TNF-α, and INF-γ with simultaneous decrease in IL-17A as well as increased fibrosis-marking genes and Tp53 expression.","PeriodicalId":336049,"journal":{"name":"The 3rd International Online-Conference on Nanomaterials","volume":"49 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Toxic Effects of Nickel Nanoparticles in a Subacute Oral Administration to Rats\",\"authors\":\"I. Gmoshinski, V. Shipelin, N. Riger, A. Balakina, N. V. Trusov, G. Guseva, S. Khotimchenko\",\"doi\":\"10.3390/materproc2022009021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": The toxic effects have been evaluated of Nickel nanoparticles (NiNPs) at their 92-day oral administration to male Wistar rats at doses of 0.1; 1 and 10 mg/kg body weight. An increase in glycemia, triglyceride, LDL, total protein, and its globulin fraction levels were noticed in NiNPs exposed rats. NiNPs caused a decrease in the reserves of reduced liver glutathione and excretion of selenium in the urine, an increase in serum levels of cytokines IL-1β, IL-2, IL-6, IL-12p70, TNF-α, and INF-γ with simultaneous decrease in IL-17A as well as increased fibrosis-marking genes and Tp53 expression.\",\"PeriodicalId\":336049,\"journal\":{\"name\":\"The 3rd International Online-Conference on Nanomaterials\",\"volume\":\"49 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The 3rd International Online-Conference on Nanomaterials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/materproc2022009021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The 3rd International Online-Conference on Nanomaterials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/materproc2022009021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Toxic Effects of Nickel Nanoparticles in a Subacute Oral Administration to Rats
: The toxic effects have been evaluated of Nickel nanoparticles (NiNPs) at their 92-day oral administration to male Wistar rats at doses of 0.1; 1 and 10 mg/kg body weight. An increase in glycemia, triglyceride, LDL, total protein, and its globulin fraction levels were noticed in NiNPs exposed rats. NiNPs caused a decrease in the reserves of reduced liver glutathione and excretion of selenium in the urine, an increase in serum levels of cytokines IL-1β, IL-2, IL-6, IL-12p70, TNF-α, and INF-γ with simultaneous decrease in IL-17A as well as increased fibrosis-marking genes and Tp53 expression.
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