瑞芬太尼与右美托咪定在全麻鼻整形术中的效果比较

Z. Ersoy, A. Uslu, BegümNemika Gökdemir, N. Çekmen, S. Jafarov
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摘要

目的比较全身麻醉下瑞芬太尼与右美托咪定在鼻整形术中的应用效果。主要结局是血流动力学、术后疼痛和恢复;次要结果为PONV、颤抖、患者和外科医生满意度。方法随机对照双盲试验,选取62例18-65岁ASA I-II级择期行鼻整形术的患者,分为两组。R组(n = 31)术中静脉滴注0.25 μg/kg/min,不加负荷剂量。D组(31例)在麻醉诱导前10 min内滴注1 μg/kg,术中静脉滴注0.5 μg/kg/h。分别于术后5分钟、30分钟和12小时评估患者的疼痛水平。评估术中血流动力学、生命参数、PONV、寒颤以及患者和手术满意度。结果瑞芬太尼和右美托咪定对血流动力学和额外镇痛需求的影响相似。两组均未发生包括PONV在内的术后并发症。右美托咪定组麻醉后恢复较快,疼痛评分较低。虽然患者满意度相似,但瑞芬太尼组的外科医生满意度更高。结论右美托咪定可作为鼻外科全身麻醉的辅助用药,安全有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the effects of remifentanil and dexmedetomidine in patients under general anesthesia for rhinoplasty
Objective We aim to compare the effects of remifentanil and dexmedetomidine administered under general anesthesia in patients undergoing rhinoplasty. The primary outcomes were hemodynamics, postoperative pain, and recovery; the secondary outcomes were PONV, shivering, and patient and surgeon satisfaction. Methods In this randomized controlled, double-blind trial, 62 patients 18–65 years of age and ASA I-II class who underwent rhinoplasty under elective conditions were accepted to the study and divided into two groups. Group R (n = 31) received 0.25 μg/kg/min intravenously infusion during the operation without a loading dose. Group D (n = 31) was initiated with a bolus of 1 μg/kg over 10 min before induction of anesthesia and then received 0.5 μg/kg/h intravenously infusion during the operation. The patient’s pain level was assessed at 5 min, 30 min, and 12 h after surgery. Intraoperative hemodynamics, vital parameters, PONV, shivering, and patient and surgical satisfaction were evaluated. Results Remifentanil and dexmedetomidine had similar effects on hemodynamics and additional analgesic requirements. No postoperative complications, including PONV, occurred in either group. Recovery from anesthesia was faster, and pain scores were lower in the dexmedetomidine group. While patient satisfaction was similar, surgeon satisfaction was higher in the remifentanil group. Conclusion We think dexmedetomidine can be used safely and effectively as an adjuvant during general anesthesia for nasal surgery.
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