生物系统的多尺度和简化模型

2015 9th International Symposium on Advanced Topics in Electrical Engineering (ATEE) Pub Date : 2015-05-07 DOI:10.1109/ATEE.2015.7133876

Ruxandra Bărbulescu, D. Ioan

{"title":"生物系统的多尺度和简化模型","authors":"Ruxandra Bărbulescu, D. Ioan","doi":"10.1109/ATEE.2015.7133876","DOIUrl":null,"url":null,"abstract":"In systems biology there is an intrinsic need for multiscale modelling, because physiological functions account for many spatial / time scales and processes, with a close connection between multi-scale, multi-physics approaches and model reduction. The paper is an overview attempting to transmit a new perspective on modelling of complex biological systems. We discuss the key points in system-level analysis and multi-scale modelling of bio-systems, making a classification of methods used in different scales and characterizing the multi-scale approach. The main contribution is the presentation of role and importance of complexity reduction in the multiscale modelling of biosystems, proposing in this respect a procedure proven to be efficient for multiphysics structures.","PeriodicalId":103513,"journal":{"name":"2015 9th International Symposium on Advanced Topics in Electrical Engineering (ATEE)","volume":"99 2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multi-scale and reduced modelling of biological systems\",\"authors\":\"Ruxandra Bărbulescu, D. Ioan\",\"doi\":\"10.1109/ATEE.2015.7133876\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In systems biology there is an intrinsic need for multiscale modelling, because physiological functions account for many spatial / time scales and processes, with a close connection between multi-scale, multi-physics approaches and model reduction. The paper is an overview attempting to transmit a new perspective on modelling of complex biological systems. We discuss the key points in system-level analysis and multi-scale modelling of bio-systems, making a classification of methods used in different scales and characterizing the multi-scale approach. The main contribution is the presentation of role and importance of complexity reduction in the multiscale modelling of biosystems, proposing in this respect a procedure proven to be efficient for multiphysics structures.\",\"PeriodicalId\":103513,\"journal\":{\"name\":\"2015 9th International Symposium on Advanced Topics in Electrical Engineering (ATEE)\",\"volume\":\"99 2 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2015 9th International Symposium on Advanced Topics in Electrical Engineering (ATEE)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/ATEE.2015.7133876\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 9th International Symposium on Advanced Topics in Electrical Engineering (ATEE)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ATEE.2015.7133876","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

在系统生物学中，由于生理功能涉及许多空间/时间尺度和过程，因此对多尺度建模有内在的需求，多尺度、多物理场方法和模型简化之间有着密切的联系。本文是一个概述，试图传递一个新的视角对复杂的生物系统建模。我们讨论了系统级分析和生物系统多尺度建模的要点，对不同尺度上使用的方法进行了分类，并对多尺度方法进行了表征。主要贡献是介绍了复杂性降低在生物系统多尺度建模中的作用和重要性，在这方面提出了一种被证明对多物理场结构有效的程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Multi-scale and reduced modelling of biological systems

In systems biology there is an intrinsic need for multiscale modelling, because physiological functions account for many spatial / time scales and processes, with a close connection between multi-scale, multi-physics approaches and model reduction. The paper is an overview attempting to transmit a new perspective on modelling of complex biological systems. We discuss the key points in system-level analysis and multi-scale modelling of bio-systems, making a classification of methods used in different scales and characterizing the multi-scale approach. The main contribution is the presentation of role and importance of complexity reduction in the multiscale modelling of biosystems, proposing in this respect a procedure proven to be efficient for multiphysics structures.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

2015 9th International Symposium on Advanced Topics in Electrical Engineering (ATEE)

自引率

0.00%

发文量