层粘连蛋白511-E8片段促进大鼠二度烧伤创面愈合

Journal of Surgery Research and Practice Pub Date : 1900-01-01 DOI:10.46889/jsrp.2022.3101

Jiraroch Meevassana, Manita Attasuriyanan, Apasee Sooksamran, J. Wititsuwannakul, Papatson Boonsongserm, Supitcha Kamolratanakul, Nichakarn Ekprachayakoon, Kevin J. Hamill, A. Mutirangura, A. Angspatt

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摘要

背景:再上皮化率是严重烧伤患者发病率和死亡率的主要决定因素。层粘连蛋白(Laminin, LM511)是一种支持上皮细胞粘附和迁移的胞外结构蛋白。LM511- e8是LM511的功能最小形式，其功效与全长蛋白相似。探讨LM511-E8碎片治疗烧伤创面是否能改善大鼠二度烧伤创面模型的创面闭合。方法:采用活体大鼠背部二度烧伤创面。将大鼠分为盐水处理组和lm511 - e8处理组，每组9只。

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Laminin 511-E8 Fragment Improves Second-Degree Burn Wound Healing in a Rat Model

Background: The rate of re-epithelialization is the primary determinant of the morbidity and mortality in patients with severe burn injuries. Laminin ⍺5β1γ1 (LM511) is an extracellular structural protein that can support epithelial cell adhesion and migration. LM511-E8 is a functionally minimal form of LM511 with an efficacy similar to that of the full-length protein. To investigate whether treatment of burn wounds with the LM511-E8 fragment improves wound closure in a rat second-degree burn wound model. Methods: Second-degree burn wounds were produced in vivo on the backs of rats. The rats were separated into saline-treated control and LM511-E8-treated groups (n=9 per group),

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Journal of Surgery Research and Practice

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