ALTERAÇÕES DA RESPOSTA IMUNE EM PACIENTES COM OBESIDADE

Objective: To carry out a narrative review on changes in the immune response in patients with obesity. This review presents an understanding of the impact that adiposity has on the function of the immune system. Methodology: Searches were performed in the Medical Literature Analysis and Retrievel System Online database (MEDLINE / Pubmed) using the descriptors Obesity; Immune response; Immune System Diseases and Disturb. Results / Discussion: It was evidenced through this study that obesity is related to several immunological changes at the cellular level. Excess fatty tissue is involved in changes in serum levels of interleukins that work to resolve inflammation, such as IL-33, in addition to an imbalance between type 1 and type 2 cytokines. Obesity was also associated with higher chances of development and therapeutic failure in rheumatic diseases, as well as changes in the concentration of type I Brazilian Journal of health Review Braz. J. Hea. Rev., Curitiba, v. 3, n. 4, p. 10945-10960 jul./aug.. 2020. ISSN 2595-6825 10947 interferon, gamma interferon, leptin and other pro-inflammatory cytokines. In addition, this pathology was associated with response and high viral load in respiratory virus infections. Conclusion: The elevated lipid profile has a considerable impact on the immune system, triggering metabolic and inflammatory disorders. These changes are related to the progression of chronic disease, changes in immunity and vaccine efficacy.