带关闭开关的温度调节系统

International Conference on Informatics Education and Research for Knowledge-Circulating Society (icks 2008) Pub Date : 2008-01-17 DOI:10.1109/ICKS.2008.15

K. Tajino, H. Hosokawa, S. Yasuda, K. Matsumura, S. Kobayashi

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引用次数: 1

摘要

在室温27摄氏度时，核心温度保持在36摄氏度。这表明哺乳动物有体温调节系统来保持核心温度。另一方面，当10%薄荷醇涂抹在皮肤上时，核心温度比正常水平升高1.0-2.0℃。这表明皮肤外周温度调节系统被TRPM8激活。腹腔注射单磷酸腺苷(AMP)，使核心温度向环境温度降低。这表明AMP切断了将核心温度维持在正常水平的体温调节系统。此外，由于没有引起寒战，AMP也阻断了trpm8介导的体温调节系统。

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Thermoregulatory System with a Shutdown Switch

At room temperature of 27degC, core temperature is maintained at 36degC. This indicates that mammals have thermoregulatory system to keep core temperature. On the other hand, when 10% menthol was applied to the skin, core temperature was increased by 1.0-2.0degC from normal level. This suggests that peripheral thermoregulatory system was activated by TRPM8 in skin. When adenosine monophosphate (AMP) was intraperitoneally injected, core temperature was decreased toward ambient temperature. This suggests that thermoregulatory system to keep core temperature around normal level was cut off by AMP. In addition, because shivering was not elicited, TRPM8-mediated thermoregulatory system was also blocked by AMP.

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International Conference on Informatics Education and Research for Knowledge-Circulating Society (icks 2008)

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