NEUROFIBROMATOSIS TYPE 2: A REVIEW OF PAIN MANAGEMENT OPTIONS

Neurofibromatosis is a chronic and painful disease process that can cause significant morbidity. The development of central and peripheral lesions is the primary source of acute and chronic pain. The pain associated with this condition is difficult to treat, but there are a number of options to make the lives of these patients more comfortable. A review of current literature and research data was used to compile a detailed list of treatment options for patients with neurofibromatosis type 2 (NF2). Key points on physiology and pain, as well as current and potential treatment options, are discussed. There are a number of articles, case reports, and studies regarding the treatment options for pain in patients with NF2. However, there is a lack of well-controlled randomized trials that demonstrate the superiority of one treatment modality. There are novel treatment plans being tailored to work at a genetic level, but these still require further research before implementing in daily practice. The management of chronic pain in NF2 is a difficult challenge for the medical community. Novel treatment options are currently being researched to improve the quality of life in these patients. Using a multimodal approach to pain control will improve the chances of a successful outcome. Key words: Neurofibromatosis type 2, schwannomatosis, neurofibromatosis type 1, chronic pain, pain management, neurofibroma, analgesics