尼日利亚三级卫生机构慢性牙周炎患者唾液乳铁蛋白水平、疾病严重程度及其相关因素

Vera E Orhue, A. Ehizele, O. Akhionbare, P. Ojehanon
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摘要

目的:本研究比较慢性牙周炎患者和非慢性牙周炎患者唾液乳铁蛋白的浓度,并探讨其与疾病临床变量的相关性。方法:选取在贝宁大学教学医院牙周病门诊就诊、符合社区牙周指数(CPI)牙周探诊深度(4mm及以上)和探诊阳性出血(BOP)选择标准的102例患者(51例和51例对照)。健康参与者(对照组)为PPD小于或等于3mm,无BOP,简化口腔卫生指数(OHI-S)不大于1.2的患者。记录基线ohi和CPI得分。采集唾液样本,采用酶联免疫吸附法进行分析。所有数据均使用社会科学统计软件包(SPSS) 22.0版进行分析。结果:对照组乳铁蛋白平均(SD)浓度为5.27(0.59)mg/l,对照组为6.74(0.61)mg/l,差异有统计学意义(p<0.001)。乳铁蛋白水平在口腔卫生“差”的参与者中最高[6.85(0.67)mg/l],在口腔卫生“好”的参与者中最低[6.65(0.83)mg/l], PPD为6mm或以上的参与者的平均浓度[6.85(0.06)mg/l]显著高于PPD为4-5mm的参与者[6.71(0.67)mg/l] (p < 0.001)。结论:慢性牙周炎患者的唾液乳铁蛋白水平高于非慢性牙周炎患者,且与疾病的主要临床特征呈正相关
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Salivary Lactoferrin Levels, Disease Severity and Correlates in Patients with Chronic Periodontitis Presenting to a Tertiary Health Facility in Nigeria.
Objective: This study compared the concentration of salivary lactoferrin in patients with and without chronic periodontitis and investigated correlations with clinical variables of the disease. Methods: The study included 102 participants (51 cases and 51 controls) who presented at the Periodontology Clinic of University of Benin Teaching Hospital and met the selection criteria of ‘4mm and above’ periodontal probing depths (PPD) and positive bleeding on probing (BOP) using community periodontal index (CPI) probe. Healthy participants (controls) were patients that had PPD less than or equal to 3mm, absence of BOP and simplified oral hygiene index (OHI-S) not more than 1.2. Baseline OHI-S and CPI scores were recorded. Saliva samples were collected and analyzed using enzyme-linked immunosorbent assay. All data were analyzed with the Statistical Package for Social Sciences (SPSS) version 22.0. Results: There was a statistically significant difference between the mean (SD) lactoferrin concentration of control participants 5.27(0.59) mg/l and case participants 6.74(0.61) mg/l (p<0.001). Participants with probing pocket depths (PPD) of 6mm or more had a significantly higher mean concentration [6.85(0.06) mg/l] than that of those with PPD 4-5mm [6.71(0.67) mg/l] (p < 0.001) Lactoferrin levels were highest in participants with ‘poor’ oral hygiene [6.85(0.60) mg/l] and lowest in those with ‘good’ oral hygiene [6.65(0.83) mg/l]. Conclusion: Salivary lactoferrin levels were higher among participants with chronic periodontitis than those without chronic periodontitis and correlates positively with the main clinical characteristics of the disease
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