{"title":"膀胱癌放射治疗的最佳分路。基于一个案例的实验。","authors":"M Mohiuddin, J McDay, D Leeper, S Kramer","doi":"10.3109/02841867909128185","DOIUrl":null,"url":null,"abstract":"<p><p>A patient with multiple metastases of transitional cell carcinoma of the bladder to the skin and subcutaneous tissues proved a model where most of the biologic and host-related factors were constant. The effects of varying the physical factors of radiation dose and time were observed. The results indicate that fractionated irradiation at intervals of 48 h was more effective than at intervals of 24 h and that superfractionation (intervals of 5 h) was not an effective method for the treatment of this tumor. The possible reasons for this effect and the implication for the treatment of bladder carcinoma are discussed.</p>","PeriodicalId":75417,"journal":{"name":"Acta radiologica: oncology, radiation, physics, biology","volume":"18 1","pages":"11-6"},"PeriodicalIF":0.0000,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841867909128185","citationCount":"3","resultStr":"{\"title\":\"Optimum fractionation for irradiation of carcinoma of the bladder. Experiments based on one case.\",\"authors\":\"M Mohiuddin, J McDay, D Leeper, S Kramer\",\"doi\":\"10.3109/02841867909128185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A patient with multiple metastases of transitional cell carcinoma of the bladder to the skin and subcutaneous tissues proved a model where most of the biologic and host-related factors were constant. The effects of varying the physical factors of radiation dose and time were observed. The results indicate that fractionated irradiation at intervals of 48 h was more effective than at intervals of 24 h and that superfractionation (intervals of 5 h) was not an effective method for the treatment of this tumor. The possible reasons for this effect and the implication for the treatment of bladder carcinoma are discussed.</p>\",\"PeriodicalId\":75417,\"journal\":{\"name\":\"Acta radiologica: oncology, radiation, physics, biology\",\"volume\":\"18 1\",\"pages\":\"11-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1979-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/02841867909128185\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta radiologica: oncology, radiation, physics, biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/02841867909128185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica: oncology, radiation, physics, biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/02841867909128185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Optimum fractionation for irradiation of carcinoma of the bladder. Experiments based on one case.
A patient with multiple metastases of transitional cell carcinoma of the bladder to the skin and subcutaneous tissues proved a model where most of the biologic and host-related factors were constant. The effects of varying the physical factors of radiation dose and time were observed. The results indicate that fractionated irradiation at intervals of 48 h was more effective than at intervals of 24 h and that superfractionation (intervals of 5 h) was not an effective method for the treatment of this tumor. The possible reasons for this effect and the implication for the treatment of bladder carcinoma are discussed.
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