足部实验:颗粒治疗中的碎片测量

A. Alexandrov, L. A. Solestizi, G. Ambrosi, S. Argirò, R. Diaz, N. Bartosik, G. Battistoni, N. Belcari, E. Bellinzona, S. Bianucci, S. Biondi, M. Bisogni, G. Bruni, N. Camarlinghi, P. Carra, P. Cerello, E. Ciarrocchi, A. Clozza, S. Colombi, G. Lellis, A. Guerra, M. D. Simoni, A. Crescenzo, M. Donetti, Y. Dong, M. Durante, A. Embriaco, M. Emde, R. Faccini, V. Ferrero, F. Ferroni, E. Fiandrini, C. Finck, E. Fiorina, M. Fischetti, M. Francesconi, M. Franchini, G. Galati, L. Galli, M. Garbini, V. Gentile, G. Giraudo, R. Hetzel, E. Iarocci, M. Ionica, K. Kanxheri, A. Kraan, V. Lante, A. Lauria, C. Tessa, E. Torres, M. Marafini, I. Mattei, A. Mengarelli, R. Mirabelli, A. Moggi, M. C. Montesi, M. Morone, M. Morrocchi, S. Muraro, L. Narici, A. Pastore, N. Pastrone, V. Patera, F. Pennazio, P. Placidi, M. Pullia, F. Raffaeli, L. Ramello, R. Ridolfi, V. Rosso, M. Rovituso, C. Sanelli, A. Sarti, G. Sartorelli, O. Sato, S. Savazzi, L. Scavarda, A. Schiavi, C. Schuy, E. Scifoni, A. Sciubba, A. Sécher, M. Selvi, L. Serv
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引用次数: 2

摘要

。带电粒子疗法(CPT)是一种治疗深部肿瘤的强大放射治疗技术,其特点是在布拉格峰区(对应于肿瘤区域)释放大剂量,并将小剂量递送到周围健康组织。精确测量带电粒子束与患者组织的核相互作用产生的碎片是改善临床治疗计划的关键任务。靶碎片实验(FOOT)是由意大利国家核物理研究所(INFN)资助的一个国际项目,旨在研究组织和粒子束碎片释放的剂量。150-400 MeV/n质子束诱导靶材(16o, 12c)破碎将通过逆运动学方法进行研究,其中16o和12c治疗束碰撞石墨和碳氢化合物靶材以提供氢的横截面。台式探测器正在开发中,它包括一个漂移室作为目标上游的光束监视器来测量光束方向,一个基于硅像素和条形探测器的磁谱仪,一个能够停止较重产生碎片的闪烁晶体量热计,以及一个具有TOF能力的∆E探测器,用于粒子识别。基于“乳化云室”概念的装置,加上电子FOOT装置的相互作用区域,将通过测量较轻的带电碎片来补充物理程序,将角度接受度扩展到约70度。在本工作中,将讨论FOOT实验的实验设计和要求,并给出乳化液光谱仪测试的初步结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THE FOOT EXPERIMENT: FRAGMENTATION MEASUREMENTS IN PARTICLE THERAPY
. Charged Particle Therapy (CPT) is a powerful radiotherapy technique for the treatment of deep-seated tumours characterized by a large dose released in the Bragg peak area (corresponding to the tumour region) and a small dose delivered to the surrounding healthy tissues. The precise measurement of the fragments produced in the nuclear interactions of charged particle beams with patient tissues is a crucial task to improve the clinical treatment plans. The FOOT (FragmentatiOn Of Target) experiment is an international project, funded by the Istituto Nazionale di Fisica Nucleare (INFN), aimed to study the dose released by the tissues and particle beams fragmentation. The target ( 16 O, 12 C) fragmentation induced by 150-400 MeV/n proton beams will be studied via the inverse kinematic approach, where 16 O and 12 C therapeutic beams collide on graphite and hydrocarbon target to provide the cross section on Hydrogen. A table-top detector is being developed and it includes a drift chamber as a beam monitor upstream of the target to measure the beam direction, a magnetic spectrometer based on silicon pixel and strip detectors, a scintillating crystal calorimeter able to stop the heavier produced fragments, and a ∆E detector, with TOF capability , for the particle identification. A setup based on the concept of the “Emulsion Cloud Chamber”, coupled with the interaction region of the electronic FOOT setup, will complement the physics program by measuring lighter charged fragments to extend the angular acceptance up to about 70 degrees. In this work, the experimental design and the requirements of the FOOT experiment will be discussed and preliminary results on the emulsion spectrometer tests will be presented.
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