Orofacial Central HyperSensitivity Syndromes: Concept, Pathophysiology, Clinical Manifestations and Therapeutic Considerations

The significant progress in scientific knowledge that Medicine and the rest of the health disciplines have experienced, especially since the late nineteenth century, have improved both the diagnostic accuracy and the medical and surgical treatments of the diseases that have historically most seriously threatened humanity (childhood diseases, respiratory and gastrointestinal infectious diseases, cardiovascular diseases, cancer). This fact has led to a rapid increase in population, a shift of the age pyramid towards older segments and the emergence of new clinical entities that, while not fatal, have in common a multifactorial etiopathogenesis and pathophysiology (genetics, epigenetics, hormones, immunity, stress, dietary, weather fluctuations...), a