{"title":"为分子电路设计DNA碱基序列的工具","authors":"Yuki Yoshida, T. Nakakuki","doi":"10.23919/ICCAS.2017.8204313","DOIUrl":null,"url":null,"abstract":"Designing a set of DNA base sequences for a large-scale molecular circuit is a difficult problem in the field of DNA computing. A DNA circuit frequently suffers from unintended DNA strand displacements among strands; this problem can ruin the desired function of a DNA circuit. In this study, our aim was to develop a computational tool for the design of DNA base sequences by means of an original algorithm based on mismatches in a DNA base sequence. Validity of the proposed algorithm is confirmed by practical redesign examples.","PeriodicalId":140598,"journal":{"name":"2017 17th International Conference on Control, Automation and Systems (ICCAS)","volume":"366 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A tool for the design of DNA base sequences for molecular circuits\",\"authors\":\"Yuki Yoshida, T. Nakakuki\",\"doi\":\"10.23919/ICCAS.2017.8204313\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Designing a set of DNA base sequences for a large-scale molecular circuit is a difficult problem in the field of DNA computing. A DNA circuit frequently suffers from unintended DNA strand displacements among strands; this problem can ruin the desired function of a DNA circuit. In this study, our aim was to develop a computational tool for the design of DNA base sequences by means of an original algorithm based on mismatches in a DNA base sequence. Validity of the proposed algorithm is confirmed by practical redesign examples.\",\"PeriodicalId\":140598,\"journal\":{\"name\":\"2017 17th International Conference on Control, Automation and Systems (ICCAS)\",\"volume\":\"366 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2017 17th International Conference on Control, Automation and Systems (ICCAS)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23919/ICCAS.2017.8204313\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2017 17th International Conference on Control, Automation and Systems (ICCAS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23919/ICCAS.2017.8204313","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A tool for the design of DNA base sequences for molecular circuits
Designing a set of DNA base sequences for a large-scale molecular circuit is a difficult problem in the field of DNA computing. A DNA circuit frequently suffers from unintended DNA strand displacements among strands; this problem can ruin the desired function of a DNA circuit. In this study, our aim was to develop a computational tool for the design of DNA base sequences by means of an original algorithm based on mismatches in a DNA base sequence. Validity of the proposed algorithm is confirmed by practical redesign examples.
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