利用包覆PNA探针的硅纳米光栅场效应管进行DNA的超灵敏电子检测

2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013) Pub Date : 2013-08-01 DOI:10.1109/NANO.2013.6720911

S. Regonda, L. Spurgin, Walter Hu

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引用次数: 2

摘要

我们报道了使用涂覆单链PNA探针的光刻Si纳米光栅(NG) FET器件对单链DNA片段的无标记快速检测。与在同一芯片上制作的单纳米线场效应管相比，ngfet具有更高的信噪比和相似的灵敏度。我们的微型场效应管的检测极限达到亚飞摩尔。同样的装置对高浓度的非互补DNA片段没有明显的反应。

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Ultrasensitive electronic detection of DNA using Si nanograting FETs coated with PNA probes

We report the label-free rapid detection of single stranded DNA segments using lithographic Si nanograting (NG) FET devices coated with single stranded PNA probes. The NGFETs shows improved signal to noise ratio and similar sensitivity in comparison with the single nanowire FETs fabricated on the same chip. The limit of detection of our finFETs reaches sub-femtoMolar. The same devices do not respond significantly to high concentrations of non-complementary DNA segments.

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2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013)

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